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Nice work Alan Brown and colleagues! Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates. academic.oup.com/nar/advance-ar…

My great pleasure to share our new Nucleic Acids Res paper! It was a great fun to determine the dynamic E3 structures and uncover an essential role of the Lrr1 PH domain for terminated CMG ubiquitylation and unloading. Grateful for everyone’s work! Alan Brown academic.oup.com/nar/advance-ar…

Thanks, Alessio! Wonder how CMG, is ubiquitylatedand unloaded during replication termination and not before? Please see our paper as well as Tom Deegan's outstanding work.

Congrats to Prof. Zhang and his team! Feel very happy for you guys as we have great comprehensive collaborations on coronavirus for many years before COVID-19 started!

Postdoctoral Research Fellow (cryo-EM of cilia) with Alan Brown Harvard Medical School, Brown Lab, Boston, USA jobrxiv.org/job/harvard-me… #ScienceJobs #cryoem

Congratulations to Brown lab graduate student Jacob R Anderson, M.D. Ph.D. on his NIH F30 award!

Near-atomic Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex biorxiv.org/cgi/content/sh… #biorxiv_biophys