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Peripheral Nerve Stimulation: Lasting Pain Relief for Some The big picture: A new study from Stanford Pain, led by Dr. Jennifer Hah, followed patients for up to three years after receiving peripheral nerve stimulation (PNS) for chronic neuropathic pain. The goal? To see how well

1/ Six years in the making! Our preprint on SORDINO fMRI is out. We're sharing the raw data and sequence to facilitate brain-wide mapping in awake, behaving rodents. If this could be useful to your colleagues and friends, please help spread the word! biorxiv.org/content/10.110…

Aerobic exercise can reverse age-related brain shrinkage. In older adults, just one year of regular aerobic activity increased hippocampal volume by 2%, effectively restoring 1–2 years of brain loss. This highlights the remarkable ability of exercise to counteract brain aging.

Chong does beautiful work—I highly encourage trainees to reach out to him!

The reasons for terminating these scientists—who have led work on neuronal migration, the role of dopamine receptors in neuronal signaling and the structure of ion channels, among other areas—remain unclear. By Sydney Wyatt, Angie Voyles Askham thetransmitter.org/science-and-so…

Want to measure behavior in freely moving animals? We've rounded up some of the most interesting and impactful open-source devices available. Check out this week's post on OpenBehavior for details and links! #OpenSource #Neuroscience edspace.american.edu/openbehavior/2…

Evolution is practical, not flawless. Here is an incredible view of a bruise on the trigeminal nerve, left by a nearby artery that strayed too close. This proximity can trigger trigeminal neuralgia, often dubbed the "suicide disease" for the excruciating facial pain it inflicts.

Brainstem roadmap

Without its international students, Harvard is not Harvard. hrvd.me/IntStudents25t

Congratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & for myself, expanding my inpatient neuropsychiatry work to the service

A new suite of harmless viruses allows researchers to target almost any type of brain cell. More in this great review on The Transmitter: thetransmitter.org/cell-types/exp… 🎥: Tanya Daigle, Emily Kussick, LifeCanvas Technologies

The disappearing funds These are the nearly 2,500 N.I.H. grants that have been ended or delayed. nytimes.com/interactive/20…

.Ardem Patapoutian, my colleagues and friend Scripps Research, and Nobel Laureate, on the front page of NYT today

1/N How do neural dynamics in motor cortex interact with those in subcortical networks to flexibly control movement? I’m beyond thrilled to share our work on this problem, led by Eric Kirk Eric Kirk with help from Kangjia Cai! biorxiv.org/content/10.110…

Pain in the brain! check out the thread: bsky.app/profile/drdami… on the new preprint: osf.io/preprints/psya…

Single-neuron projectome reveals organization of somatosensory ascending pathways in the mouse brain: Neuron cell.com/neuron/fulltex… Whoa!

Inspired by Michael Eisen I've begun an experiment in open science. We are sharing our ongoing work on psychedelic signaling here: open.substack.com/pub/zendudest/… I've decided to make this 'open' as the experiment are of immediate interest to the field and I'll write them up later.

Check it out! The new interactive website for pain researchers around the globe is live! Webinars, podcasts, interviews and the fan favorite: Papers of the Week! You'll also find lively discussions, jobs, meetings, funding opportunities and more! painresearchforum.org

New electron microscopy study in Nature Neuroscience finds that layer 5 ET neurons mostly connect to inhibitory cells locally, esp. those suppressing other excitatory cells, suggesting a "winner-take-all" system. nature.com/articles/s4159…

🎵⚡ Musical beats can enhance TMS effects! Our "Sensory Entrained TMS" uses music to optimize brain stimulation timing - a simple, accessible approach that could improve plasticity protocols and TMS treatments. Wu Tsai Neurosciences Institute Jessica M Ross, PhD Corey Keller