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A screening platform using a photoaffinity-labelled amine fragment library allows identification and profiling of new fragment-protein interactions - exciting news in drug discovery from Jacob Bush and co-workers at GSK and Chemistry - University of Strathclyde in Angewandte Chemie: onlinelibrary.wiley.com/doi/full/10.10…

Enjoyed yesterday’s #Collaboration2020 virtual event at Syngenta UK featuring a poster from our very own Josh Linfoot - looking forward to an excellent day two!

A newly optimized iodoarene catalyst for the enantioselective synthesis of difluorinated alkyl bromides, with supporting computational studies - nice work from Jacobsen Lab and colleagues at Harvard Chemistry in J. Am. Chem. Soc.: pubs.acs.org/doi/pdf/10.102…

Individual resonances in overlapping multiplets can now be selectively excited in NOESY experiments using the rapid GEMSTONE approach, developed by Peter Kiraly, Ralph Adams and colleagues at UoM Chemistry in Angewandte Chemie: onlinelibrary.wiley.com/doi/epdf/10.10…

Brønsted acid-catalysed enantioselective reactions that proceed through the non-classical 2-norbornyl carbocation - awesome paper from AK List and co-workers at the Max Planck Institute in Nature Chemistry: nature.com/articles/s4155…

In this week's episode we're joined by César Adriano Bauer (alumnus of the Arion group, Gentilucci and Spivey Group, MaulideGroup and postdoc at Baran Lab) who takes us through his work on cyclopropanation by oxidative umpolung published in Angewandte Chemie! youtu.be/wwuIT8CVQAs

Xavier morelli CNRS 🌍 @unilim Lieven Meerpoel @JanssenBelgium Institut Pasteur, since 1887 (PLENARY - suite et fin) Spivey Group Imperial College London Dom Bonnet - E. Saada-Bouzid #Nice Julie Broggi ICR Institut Chimie Radicalaire

Congratulations Herzon Lab for your total asymmetric synthesis of the Celastraceae natural product core euonyminol in J. Am. Chem. Soc.. Super impressive! Look forward to seeing one of the cathedulin bis-macrocycles yielding to chemical synthesis soon. ACS pubs.acs.org/doi/10.1021/ja…

New #PhD #studentship sponsored by AstraZeneca available in my group in collaboration with @BeckyLGreenaway and Spivey Group on C–H functionalisation. Funding at UK levels. Interested candidates please get in contact by email.

Hot off the press! Check out our Mechanism of the Month piece on MIDA-Directed meta-Selective C-H Functionalizations in Trends in Chemistry - from Josh Linfoot and Alex Williams: authors.elsevier.com/a/1cmCR9CpcYOz…

AACR RESEARCH GRANT WINNERS ANNOUNCED! 🏆 Congratulations to Jerry Xiao and Stanislav Piletsky. Both winners are awarded $1000 towards their cancer research. Thank you to all who entered #cancerresearchgrant More info: ptglab.com/news/company-n…

This morning we're talking about the novel idea of skeletal editing by N-atom deletion, discussing the interesting approaches from Levin Group at UChicago Chemistry in nature (nature.com/articles/s4158…) and the Lu Group at Nanjing University in Angewandte Chemie (onlinelibrary.wiley.com/doi/epdf/10.10…)!

Great paper from the Balasubramanian group at Cambridge Chemistry in Nature Chemistry on probing the interactome of G-quadruplexes using co-binding-mediated protein profiling: nature.com/articles/s4155…

Directed evolution engineers an enzyme to catalyse the asymmetric alkylation of ketones - a nice read with some interesting mechanistic discussion from Frances Arnold in Angewandte Chemie: onlinelibrary.wiley.com/doi/epdf/10.10…

For anyone at #MQSS2022 this week, our PhD student Josh Linfoot is presenting a poster at stand 8 - come say hi to find out about proteomics for insecticides! MaxQuant

Scientists led by Bill Morandi Morandi Lab #LOC developed a simple method for converting the #indole group into other important structural elements. This facilitates the search for pharmaceutically active substances. Read more on: doi.org/10.1126/scienc… ethz.ch/en/news-and-ev…

Thanks RWTH Aachen Aachen for a great new year symposium with Schoenebeck Group Leonori Lab Spivey Group and thanks to our hosts / organising committee / ⁦Bayer AG⁩

Very excited to make our latest group trip to #BSM2023 - so happy to see the meeting return, and with such a strong line-up of speakers!

From alchemist to AI chemist nature.com/articles/s4157… A Comment article by @BeckyLGreenaway, Kim Jelfs, Spivey Group, & Sophia N. Yaliraki at ImperialDigiFAB, Imperial Chemistry on the use of AI when training future generations of chemists.

Enantioenriched spirocyclic azetidine oxindoles prepared using an SF5-containing chiral phase-transfer catalyst, reported in #OrgLett by Bull Group Chemistry, Spivey Group, and coworkers Imperial Chemistry. Check it out: pubs.acs.org/doi/10.1021/ac…