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Check out this new #RedJournal article from @nrgonc on a comprehensive molecular analysis in NRG Oncology/RTOG 9813: A Phase III study of radiation and temozolomide vs radiation and BCNU/CCNU in anaplastic astrocytoma: tinyurl.com/redfleming

Meningiomas & copy number alterations · Gr 1 mening: Loss 1p Median PFS 6 yrs vs 35 yrs · Outcomes Gr1 mening 1p loss ≈ Gr2 · Outcomes 1p loss & 1q gain ≈ Gr3 jamanetwork.com/journals/jamao…

Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33 dlvr.it/TKkwpF

🚨BREAKING: RAVENS Trial Redefines Oligometastatic Prostate Care! 🚨OncoAlert 🎯 Objective: • Assess if Ra223+ SABR) delays progression in bone omCSPC by targeting subclinical disease 🏥 Methods: • RCT w/ 64 👥 (1:1 randomization) • Eligibility: ≤3 bone metastases

I am pleased to share our recent publication, fruit of a wonderful collaboration with amazing colleagues Adrienne Boire and Jan Remsik, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> nature.com/articles/s4158…

Excited to share our recent nature paper! nature.com/articles/s4158… Tremendous collaborative effort from UChicagoCancerCenter The University of Chicago University of Chicago Radiation Oncology Ralph Weichselbaum

STAT5 and STAT3 balance shapes DC function and tumor immunity nature nature.com/articles/s4158…

FDA approves belzutifan for pheochromocytoma or paraganglioma | FDA fda.gov/drugs/resource…

5) To further clarify the full cell circuit see the image below: T cells produce IFNγ, supporting maturation of conv DC2 cells into migratory CCR7+ DCs. These DCs produce IL-12 and IL-15 to support the survival and proliferation of NK cells, which control metastatic cells.

Great publication! fSRS also useful for intramedullary metastases. Here’s a case from a patient with metastatic pancreatic neuroendocrine:

Bommireddy et al. Samuel Chao Samuel Chao reported on a predictive model for radiation necrosis after SF-SRS for brain metastases, identifying risk factors including tumor size, histology, hemorrhage, and dosimetry across four groups. #JNO Read more:link.springer.com/article/10.100…

Our team found in an expanded analysis of our spine SRS patients that endplate disruption continues to matter for late vertebral fracture post therapy. But also important use of steroids > 4 weeks. OhioStateRadOnc Ohio State Neurosurgery Residency pubmed.ncbi.nlm.nih.gov/40369591/

Results from FAST-Forward Nodal substudy published in Radiotherapy & Oncology ➡️26 Gy/5Fr non-inferior to 40 Gy/15Fr for hand swelling at 5 years ➡️No cases of radiation-induced brachial plexopathy ➡️Other patient-reported outcomes were similar 🔗doi.org/10.1016/j.rado…

☄️Neoadjuvant stereotactic ablative body radiotherapy for renal cell carcinoma (RCC) with thrombus: do, or do not? 👌Nice overview of the scarce data published by Jennifer Le Guévelou Laurence Albiges Shankar Siva and Karim Bensalah Paper online here 👇👇 sciencedirect.com/science/articl…

Dosimetric Constraints Brainstem SRS · 103 mets, 21 AVMs involving brainstem · Keep Brainstem D0.5 cc<15Gy · Recommend sharp dose fall-off (↓↓ isodose prescription/↑↑ max dose) sciencedirect.com/science/articl…

🚨 Randomized Trial: Significantly less symptom burden with SRS compared to HA-WBRT. SRS Standard of Care for 5-20 brain mets 🚨🚨🚨

#ASCO25 Final CATNON trial results confirm: adjuvant TMZ (not concurrent) improves OS in IDH-mut anaplastic glioma (12.5 yrs vs 1.7 yrs in IDHwt). No added benefit from concurrent TMZ. RT→adjTMZ remains standard for IDHmt, 1p/19q-intact disease #btsm 🔗 meetings.asco.org/abstracts-pres…

🚨 Placebo Controlled Randomized Trial: Memantine given w/Brain RT Improved Cognitive Outcomes & QOL 🚨🚨🚨

Congratulations to all awardees‼️ 👏👏👏 🔊Shoutout to Amy Wisdom, MD, PhD Holman resident at Harvard Radiation Oncology Program for her pioneering work in the GBM immuno space🧠🐁 #radonc #btsm Stefani Spranger Koch Institute at MIT Brigham and Women’s Radiation Oncology Mass General Cancer Center David Kirsch, MD, PhD Radiation Research Society Ari E. Marciscano, MD

🚨Update Randomized Trial: Significantly Better KPS & Cognitive Function with SRS compared to HA-WBRT for 5-20 brain mets 🚨🚨🚨