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🚨 New study CMGH Erythropoietic protoporphyria (EPP) & liver disease 💊An OTC antihistamine (chlorcyclizine) might help 🎯Chlorcyclizine lowered PP-IX levels and reduced liver damage 🧪Repurposing antihistamines for possible EPP treatment 🔗cmghjournal.org/article/S2352-…

Can you think of a time you’ve felt stress/anxiety through gastrointestinal symptoms or the “nervous stomach”? Now there’s more research than ever proving the gut really is the second brain… American Gastroenterological Association (AGA) UCLA Gastroenterology and Hepatology #GITwitter #MedTwitter CMGH

⭐Read Now⭐ 📖 This study highlights the Bcl3-Nrf2 axis as a potential target for mitigating APAP hepatotoxicity. Liver Research /Oxidative Stress /Nrf2 🔗 ow.ly/jUgr50VXPqe

📚#EditorsEssentialReading in CMGH Extracellular vesicles released from adipose tissue in obese mice induce colonic fatty acid oxidation, growth, and stemness - helping define adipose-intestine communication & obesity-related GI disorders 🔗: cmghjournal.org/article/S2352-…

⭐ Featured Article ⭐ 📑 Inhibition of Ribosome Biogenesis In Vivo Causes p53-Dependent Death and p53-Independent Dysfunction 🔗 ow.ly/BYxt50VXPOB

From CMGH: an experimental study in zebrafish suggested antihistamines may be a strategy for treating erythropoietic protoporphyria-associated liver disease. Check out our coverage plus clinical takeaways from Dr. Brian DeBosch: ow.ly/6xwq50VU8Jj

⭐ This review article provides "strong evidence that DRA may serve as a novel therapeutic target with dual benefits in not only correcting diarrheal phenotype but also improving gut barrier integrity and inflammation in pathogen infection or IBD." 🔗 ow.ly/PeAF50VXQVw

🌟 As part of the continued 10th anniversary celebration, James R. Goldenring highlights the foundation and continued growth of CMGH. 🌟 ▶️ #CelebrateCMGH and watch the video here: ow.ly/F41h50W1VKT

📑 Preclinical study showed in several experimental systems that antihistamines, such as well-known allergy drugs, are also porphyrin-lowering agents that protect from liver damage in the disorder erythropoietic protoporphyria. 👨‍⚕️ Rutgers Health 🔗 ow.ly/t9aO50W1ww7

📖 This innovative study identifies changes to the zonation of the cytokine CXCL9 in liver sinusoidal endothelial cells in congestive hepatopathy and Fontan associated liver disease. 📣 Read more on this study! ⬇️ 🔗 ow.ly/7xoE50W1x9T

⭐ This featured article focuses on a study where a group "identified a crosstalk between the Nrf2 and NF-κB transcription factors in hepatocytes of the normal and regenerating liver." 🖱️ Click the link to read more! ⬇️ 🔗 ow.ly/VMkW50W1ygk

#IBS with diarrhea involves “allergic type” white blood cells (type 2 and type 9 T cells) in the intestines. This may be another clue to how #IBD with diarrhea develops. 🔗 ow.ly/gE6z50W1z3m

⭐ Check out this article/editorial pair! Article 🔗 ow.ly/ysur50W1zih Editorial 🔗 ow.ly/I4tu50W1zie

📑 Check out this review article that "highlights that DRA may serve as a novel therapeutic target for diarrheal diseases, with dual benefits in diarrheal phenotype and gut inflammation in pathogen infection or #IBD." 🔗 ow.ly/QAji50W1zFv

⭐ Check out this newly published research that identifies SIRT2 as a tumor promoter in hepatocellular carcinoma (HCC), suppressing GADD45γ via C/EBPβ. Targeting SIRT2 could be a promising therapeutic strategy for HCC. 🔗 ow.ly/87p550W91zz

📣 The newest issue of CMGH has dropped! 🔗 ow.ly/ugVf50W8Zo8

⏲️ Turn your clock back to 2021 to read one of the top articles from that year! ⭐ Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model 🔗 ow.ly/7m4C50W96c8

🔔 #IBD is a chronic relapsing inflammatory disorder of the gastrointestinal tract. 📑 Read more on #IBD with this article that follows the "Progression of Chronic Inflammatory Bowel Disease in Mice". 🔗 ow.ly/QKKn50W9NQ5

🔔 A New Player in Liver Fibrosis Therapy! This study reveals Periplakin reprograms CD44Low to CD44High liver progenitor cells, suppressing fibrosis. ➡️ Read more 🔗 ow.ly/AE8N50W9NR7