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Irene Cózar y Germán Perdomo impartieron charlas en el Instituto de Investigación en Diabetes de City of Hope sobre el papel de IDE en las células alfa pancreáticas y el hígado

City of Hope diabetes experts present new research on beta cells, insulin secretion and islet transplantation at annual American Diabetes Association (ADA) Conference cityofhope.org/city-hope-diab…

1/ Debbie C. Thurmond, Ph.D., and Rama Natarajan, Ph.D., are the recipients of a prestigious grant from the NIH. The grant will support the Institute's predoctoral fellowship interdisciplinary training program. Learn more: cityofhope.org/academics/irel…

.Jenna Lynn Collier, Sharpe et al. Harvard Medical School identify unique features of diabetogenic T cells in the pancreas and peripheral tissues between anti-PD-1-induced type 1 #diabetes (T1D) and spontaneous T1D in non-obese diabetic mice bit.ly/43mAeKb Dillon Patterson

📢 TOMORROW - Thursday 7/13 (9 am PT//12 pm EST) Adolfo Garcia Ocaña. Ph.D. Geming (Brian) Lu MPI-CBG Dresden Randy Kang @einsteinmed Richard Benninger Erez Dror @bruskolab XX Jasmine Maghera UF Medicine UF Diabetes Institute Stephen Rich Kyle Gaulton #epigenetics #betacells #T1D 📷tinyurl.com/42fswwt6

In one of Garcia-Ocaña’s presentations at #ADA2023, his team highlighted a new approach to identifying different alpha cell subtypes that produce glucagon, and their potential to convert to insulin-producing beta cells in the body. Read: cityofhope.org/diabetes-exper… Adolfo Garcia Ocaña. Ph.D.

Happy to be addressed by the City of Hope presss again. Alpha cell and alpha-beta plasticity is so exciting subect to investigate Adolfo Garcia Ocaña. Ph.D.

A Postdoctoral position is available for a highly motivated individual in the laboratory of Adolfo Garcia-Ocaña, Professor and Chair of the Department of Molecular and Cellular Endocrinology at the Arthur Riggs Diabetes and Metabolism Research Institute. cityofhopejobs.org/job/postdoctor…

Finally the second paper is on Biorxiv. It has been a while, and first one in COH! biorxiv.org/content/10.110…

Most importantly, they illustrate the importance of studying human islets in their natural in vivo setting - Detail in thread!! biorxiv.org/content/10.110…

Can alpha-beta cell trans-differentiation modeled in integrative scRNA & snRNA seq data? Details in thread #diabetes #T2D #CityofHope #singlecell #sequencing #bioinformatics biorxiv.org/content/10.110…

1) There are five different GCG-expressing human α-cell subclusters [α1, α2, α-β-transition 1 (AB-Tr1), α-β-transition 2 (AB-Tr2), and α-β (AB) cluster] with different transcriptome profiles in human islets from non-diabetic donors.

Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases. sciencedirect.com/science/articl…

ADA Annual Meeting in Orlando, FL, June 23, 2024: Fantastic oral presentation delivered by Dr. Geming Lu about ZNF385D, a novel gene in beta cells detrimental for beta cell function. Diabetes Experts Present New Treatment Possibilities at ADA Conference cityofhope.org/diabetes-exper…

City of Hope and Mount Sinai scientists first to demonstrate a combination treatment can increase human insulin-producing cells in vivo cityofhope.org/city-of-hope-a… The related work is published in Science Translational Medicine. science.org/doi/10.1126/sc…

AOP #ResearchHighlight: a combination of a #GLP1RA and a DYRK1A inhibitor greatly increases human β-cell mass in #diabetic mice (£) go.nature.com/3Ys0mo1 Adolfo Garcia Ocaña. Ph.D. City of Hope Icahn School of Medicine at Mount Sinai

Please join us Thursday Nov. 14: Adolfo Garcia Ocaña. Ph.D. on therapeutics for beta cell regeneration.