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Incredibly fun to work with Alireza Ghanbarpour and Bob Sauer on this project - read more here: biorxiv.org/content/10.110…. Also, exciting things brewing in the Ghanbarpour lab at WashU, be sure to check out Ali's new group (sites.wustl.edu/ghanbarpour/)!!

Congratulations to graduate students @AMohamed_98 from our group and Peter Wang from the Bartel lab on determining the structure of human AGO2 in the slicing conformation. This was a challenging project with many exciting results. Read our preprint to learn more!

The Farnung Lab is looking for post-doctoral researchers that want to join our team! If you are interested in chromatin, transcription, genome organization, and other processes that take place in the nucleus, consider applying to our lab! FarnungLab.com

1. Excited to share our paper in Science Advances. We developed an antigen-based CAR-PET imaging approach that enables in vivo detection of CAR T-cells with high sensitivity and specificity, without requiring genetic alterations. Here’s a brief thread:science.org/doi/10.1126/sc…

I’m excited to share our latest preprint, where we showcase the development of two computational tools to facilitate the analysis of highly heterogeneous cryo-EM datasets. (1/7) biorxiv.org/content/10.110…

New work from our lab by the amazing Laurel Kinman, Maria V. Carreira, and Barrett Powell here: biorxiv.org/content/10.110…. Our lab has found SIREn super useful, and I expect you will too! Also, check out the soon-to-be-announced Kinman lab UC San Francisco...exciting days ahead!!!

I am looking for a highly talented postdoc to join my lab to study ATP-dependent AAA machines using structural biology, biochemistry, and mass spectrometry. Please apply through the following link: bit.ly/4haSZID For more information, visit: sites.wustl.edu/ghanbarpour/

Excited to share our latest work in Nature Communications! We've captured an AAA proteolytic machine in action, right as it poised to unfold its substrate for degradation—a first-ever glimpse into this long-sought, elusive step in AAA proteolysis! Enjoy! rdcu.be/dZzRR

MIT Biology featured my recent work on AAA proteases, done in collaboration with Bob Sauer and @Jhdavis! Check it out if you'd like to learn more about these amazing molecular machines. MIT Biology bit.ly/4fKUWd2

Joey Davis @[email protected] Alireza Ghanbarpour use cryo-EM to visualise AAA proteases unfolding substrates before degradation nature.com/articles/s4146…

First holiday party for the Ghanbarpour Lab, including my junior scientist in training!

A new paper published out of the Rui Zhang lab! Check it out here: nature.com/articles/s4158…!

My lab WUSM Biochemistry and Molecular Biophysics is hiring! We’re looking for a talented Postdoc and Research Tech to join us in studying the structure and function of molecular machines and massive membrane protein assemblies. Apply here: Postdoc: bit.ly/4hG0Ai3 Research Tech: bit.ly/4aVEWni

Excited to share that our recent story on how massive membrane assemblies of HflK/C regulate protein degradation by FtsH AAA proteases is now online in @EMBOJournal. Check it out and enjoy! embopress.org/doi/full/10.10… #StructuralBiology #Proteases #MembraneProteins