We are recruiting for a postdoc to join our group at Amgen Oncology in Thousand Oaks, California. This is a great opportunity to learn about drug discovery while having the scientific freedom to engage in curiosity-driven research and publish your results.careers.amgen.com/en/job/thousan…

Congrats Sergi, Connor and team!

Today’s U.S. FDA approval is a landmark achievement in the evolution of small cell lung cancer care - demonstrating Amgen 🧪🔬🧬’s continued success against the toughest cancers and reaffirming our commitment to relentlessly innovating for patients. #MyCompany

Always wanted a chromosome stuffie

Today's U.S. FDA decision to expand use of Bispecific T-cell Engager (BiTE®) immunotherapy to adult patients receiving front-line B-ALL therapy is a major milestone in the care of leukemia patients. As a hematologist who cared for patients with ALL just prior to joining Amgen 🧪🔬🧬, I

Cilia are beautiful

📝Preprint! 1️⃣Question: How are large MTOC structures regulated by an E3 ligase? 🧵In 2020, we showed TRIM37 suppresses surrogate MTOC structures in 17q23 cancers, see ⬇️). But TRIM37 also regulates centrosomes and pathological MTOCs (Gönczy/Oegema/Desai labs). How?? ➡️our model

2️⃣ Model: My work at Andrew Holland suggests a shared blueprint within the TRIM family for assembly regulation. Akin to TRIM5a in HIV restriction, TRIM37 employs an assembly-driven E3 activation process but is uniquely tailored for MTOC control via its TRAF domain. ➡️Impact

Full preprint here: biorxiv.org/content/10.110… we welcome feedback and questions, thanks! 🙏

Mesoscale regulation of MTOCs by the E3 ligase TRIM37 dlvr.it/TFRbdj

Curious about how cells generate mechanically stiff invasive protrusions from branched actin filaments? Check out our paper published today in Nature Cell Biology! Congratulations to Yue Lu and all co-authors for a beautiful piece of work! nature.com/articles/s4155…

We got a puppy 😍

Three papers accepted in one week. That won’t ever happen again….

BREAKING: Johns Hopkins along with 12 peer institutions and Assoc of Amer Univ sues to stop drastic cuts in NIH funding. This is separate from lawsuit brought by 22 states, which also includes Maryland. Hopkins prez cites our 600 clinical trials that would be crippled by the cut.

Things I wish more people knew about doing science in the US (thread):

Check out our latest paper in Journal of Cell Biology. Congrats to the entire team, especially Ana Curinha

Check out our latest work using the AID2 system to control the levels of an essential protein in mice. Congrats to the entire team, especially @SladkyValentina and Margaret Strong science.org/doi/10.1126/sc…

Centriole structural integrity defects are a crucial feature of hydrolethalus syndrome, say Ana Curinha (Ana Curinha), Andrew Holland Andrew Holland Johns Hopkins University and colleagues: hubs.la/Q038zmjt0 #Centrioles #Cilia