In hypertensive models, BCAA catabolism of cardiomyocytes is damaged causing an obvious accumulation of valine, and promoting an imbalanced MQC w/ the inhibited mitophagy and excessive mitochondrial fission 🔗atherosclerosis-journal.com/article/S0021-… European Atherosclerosis Society

This review dives into the physiological roles of ANGPTLs, particularly ANGPTL3, ANGPTL4, and ANGPTL8, which inhibit LPL and modulate lipid and triglyceride metabolism according to nutritional states 🔗atherosclerosis-journal.com/article/S0021-… European Atherosclerosis Society

The #Exposome: Rethinking Environmental Impacts on NCDs account for 2/3 of global deaths each year — largely driven by environmental stressors such as pollution, climate change, urban noise, and socioeconomic factors 🔗 atherosclerosis-journal.com/article/S0021-… European Atherosclerosis Society #CvPrev

More aggressive anti-inflammatory therapy may have additional value in patients with spotty calcification 🔗atherosclerosis-journal.com/article/S0021-… European Atherosclerosis Society

New in @EurJCardiol: “Beyond the Mean” by Pirillo & Catapano. High LDL-C variability = +34 % MACE & ↑ mortality—even when average LDL is on target. Time to monitor stability and area under the curve? #CardioTwitter #lipids #residualrisk academic.oup.com/eurjpc/advance…

This study, utilizing novel NLP methods for the first time in aneurysm research, contributes to the growing understanding of the role of platelets in aortic aneurysm progression and the potential impact of antiplatelet therapy 🔗atherosclerosis-journal.com/article/S0021-… European Atherosclerosis Society Shayan Mohammadmoradi, MS, PhD

Targeting ANGPTLs could represent a promising strategy to reduce residual cardiovascular risk and complement existing lipid-lowering therapies 🔗atherosclerosis-journal.com/article/S0021-… European Atherosclerosis Society @ELS_Cardiology #EASSoMe #CvPrev

Spotty calcification might be useful to identify patients at higher risk for future cardiac events 🔗atherosclerosis-journal.com/article/S0021-… European Atherosclerosis Society #EASSoMe

The exposome offers a vital lens for future research, policy, and preventive cardiovascular medicine, helping to address the health burden posed by our changing environment 🔗 atherosclerosis-journal.com/article/S0021-… European Atherosclerosis Society #EASSoMe

New #SISA consensus out! “Plasma triglycerides & cardiovascular disease” → TG-rich lipoproteins = still a big residual risk. Key takeaways: updated goals, lifestyle + novel drugs (apo-CIII / ANGPTL3). #lipids #cardio #atherosclerosis sciencedirect.com/science/articl…

EuroPath survey post-ACS•LDL testing↑Non-HDL-C, Lp(a) tests↑Statin/ezetimibe/PCSK9↑ academic.oup.com/eurjpc/advance…

New meta-analysis on lipid-lowering drugs & #Lp(a) shows: • PCSK9 mAbs, inclisiran, CETP-i & niacin ↓ Lp(a) • Greater absolute drop when baseline Lp(a) is very high Still no therapy dedicated to Lp(a) – big gap for #CVrisk research atherosclerosis-journal.com/article/S0021-…

New meta-analysis (21 774 pts) shows low-dose #colchicine cuts major CVE by 26 % (RR 0.74) when given ≥12 months in secondary prevention. MI ↓15 %, stroke ↓21 %;. Anti-inflammatory add-on to standard care looks stronger than ever.   onlinelibrary.wiley.com/doi/10.1111/jo…

Multiomics in atherosclerotic cardiovascular disease - Atherosclerosis atherosclerosis-journal.com/article/S0021-… The future is now. Beautifull review from AtheroNet group. Proud of taking part of this action!

Only 1 in 3 Italian secondary‑prevention pts hit LDL‑C < 55 mg/dL in the #BRINGUP registry (n = 4 790). At discharge Statin + ezetimibe  74 %, but PCSK9/i use still low. Big room for more intensive therapy! #CardioTwitter #lipids internationaljournalofcardiology.com/article/S0167-…

Spotty calcification is positively associated with features of plaque vulnerability, such as lipid-rich plaque and macrophage 🔗atherosclerosis-journal.com/article/S0021-… European Atherosclerosis Society #EASSoMe

Our new study on UK Biobank shows that Family history and polygenic burden add up—independent of LDL‑C. #CardioTwitter #genetics #polygenicriskscore sciencedirect.com/science/articl…

The exposome interacts with genetics and pre-existing conditions, affecting vulnerable populations most. Advances in exposomic science may help explain and mitigate diseases like atherosclerosis 🔗 atherosclerosis-journal.com/article/S0021-… European Atherosclerosis Society #EASSoMe

Clinicians think 40 % doubt LLT need—actual 64 % • 40 % treatment concerns—actual 79 % • Info unmet 32 %—actual 75 % Yet 82 % pts accept intensification (docs guess 55 %). tandfonline.com/doi/full/10.10…

Up to date with out Lp(a) review paper High levels ↑ ASCVD & aortic stenosis risk—yet most pts never tested. Novel therapies reduce Lp(a) >80 %. Time to add Lp(a) to routine risk checks and prep for outcome trials! #CardioTwitter #lipids sciencedirect.com/science/articl…