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Sarah told me that with this experimental therapy —personalized deep brain stimulation — when her depression starts, “suddenly the ultra-rational side of you comes on and those emotions can be separated.” nytimes.com/2021/10/04/hea… 1/7

Case report describes a #biomarker driven closed-loop therapy for depression using implanted electrodes to continually sense brain activity and automatically trigger direct brain electrical stimulation in high #depression states. Katherine Scangos ChangLabUCSF nature.com/articles/s4159…

Way to go Joline Fan MD, MS of UCSFepilepsy who received the 2021 Physician Scientist Fellowship from the Doris Duke Charitable Foundation (DDCF) for “Global and Regional Brain Network Properties of Sleep-Wake States as Drivers of Ictogenesis” ddcf.org/news--insights…

Multisite RNS biomarker paper now out in Epilepsia (doi.org/10.1111/epi.17…)! Thanks to the incredible collaborative efforts with NYU & UCSF, we identified an iEEG network biomarker that differentiates RNS responders from non-responders prior to device implantation.

From logical reasoning to mental simulation, recurrent neural networks (RNNs) possess an incredible capacity for computation. To fully harness this capacity, we developed a programming language for RNNs arxiv.org/abs/2203.05032. Here is a game of pong programmed inside of an RNN.

Bernabei et al. construct an atlas of normative interictal intracranial EEG recordings, and show that brain regions that generate spikes and seizures display patterns of activity and connectivity that deviate from those seen in the atlas. bit.ly/3m2HQho

Excellent work demonstrating the potential value add of chronic brain recordings and cycles in programming of closed-loop stimulation devices!

Momentary snapshots of hippocampal brain activity may provide daily seizure forecasts in epilepsy @UCSFEpilepsy, UCSF Neurosurgery, Ankit N. Khambhati, @ChangLabUCSF #seizurecycles, #epilepsy nature.com/articles/s4159…

Congratulations to our spectacular epilepsy fellow Sharon Chiang and brilliant division chief Vikram Rao for their new paper in BRAIN: State-dependent effects of responsive neurostimulation depend on seizure localization academic.oup.com/brain/article-…

Momentary snapshots of hippocampal brain activity may provide daily seizure forecasts in epilepsy @UCSFEpilepsy, UCSF Neurosurgery, Ankit N. Khambhati, @ChangLabUCSF #seizurecycles, #epilepsy nature.com/articles/s4159…

Forecasting #seizures using #neural snapshots offers new hope for #epilepsy patients, potentially improving their quality of #life and #safety. -By Ankit Khambhati and Vikram Rao UC San Francisco buff.ly/3MnDkHN #brainactivitysnapshots #brainimplanttech #epilepsyprediction