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So many novel antiphage systems out there! Hard to keep up with the pace of discoveries? We reviewed for Nature Reviews Microbiology the highly diverse antiphage defence systems of bacteria; from molecular mechanisms to evolutionary drivers of such diversity. rdcu.be/dg3ql

Just posted our new study biorxiv! We developed a CRISPR-based RNA editing technology that is conceptually similar to “break-and-repair” DNA editing. A thread by Artem Nemudryi, PhD is below.

Our study is on the cover! 😍

📢I'm hiring! Postdocs, PhDs, and Research Techs at Dept. of Penn Biology at Penn! We'll use bioinformatics 🖥️, biochem 🧪, and cryo-EM ❄️🔬, to study how CRISPR systems work & applications. Work on cool science with a supportive mentor! web.sas.upenn.edu/sanfrango-lab/ RTs appreciated!

I’m excited to share the preprint of my first first-author paper! The pandemic was a challenging time to start my PhD, but it spawned the awesome opportunity to join a second lab 800 miles west in Seattle to study ancient viruses in the human genome! 🧵👇

Our CRISPR-based RNA virus engineering study was covered in the latest #TWiV 1045 episode 🎙️🦠 Thanks Vincent MicrobeTV, Rich Condit, Brianne Dr. Brianne Barker, Alan, and Angela Angela R. Mingarelli for a very thoughtful discussion of our work!

Combination of type III CRISPR-based RNA cleavage with splinted RNA ligation makes programmed deletions and insertions in target RNA sequences for viral engineering #NBThighlight bit.ly/458gaf6

One man's niche is another man's treasure 😀

’This is just the beginning’: RNA editing set to democratise viral engineering: chemistryworld.com/news/this-is-j…

Why do phages encode tRNAs? It aids in defeating tRNA-targeting immune systems. We provide structure and mechanism for the PARIS defense and show how it cleaves host tRNA upon trigger sensing. Stikingly, the non-cleavable tRNA of T5 supports the infection. biorxiv.org/content/10.110…

It turns out that nidoviruses aren’t the only ones playing the long game. We found an ultra-long flavi-like virus in a sea sponge metatranscriptome. It’s a weird one… Preprint: biorxiv.org/content/10.110…

Cellular repair of DNA breaks enables editing of the human genome. Do human cells repair RNA breaks, and can we use it to edit transcriptomes? Our work with Anna Nemudraia and Wiedenheft Lab is now online in Science Magazine! #ScienceResearch science.org/doi/10.1126/sc…

Oh boy! I’m very interested, please, check your DM! 😆😜

New article from Will Henriques @janet_young_123 Artem Nemudryi, PhD Anna Nemudraia Wiedenheft Lab Harmit S. Malik: The Diverse Evolutionary Histories of Domesticated Metaviral Capsid Genes in Mammals buff.ly/3U5QZX7 #science #evolution #biology #genome

Montana State scientists’ research on RNA editing illuminates possible lifesaving treatments for genetic diseases montana.edu/news/23722/mon…

I am delighted to share the newest work from the Sternberg Lab, in which we discover RNA-templated gene creation as a mechanism of antiviral immunity. This is a story for anyone who loves molecular biology, and one that repeatedly left us in disbelief. doi.org/10.1101/2024.0…

Check out the latest story from the Sternberg group: phages coopted transposon-encoded nucleases (TnpB) and repurposed them for regulation of host genes! nature.com/articles/s4158… Thrilled to see this work in print, & a huge thanks to my amazing co-authors!!

It has recently been described that bacteria and eukaryotes share some part of their immune systems. But what do they share exactly? How did this evolve? We propose the concept of ancestral immunity to explore this emerging topic. Some answers but mostly questions 🙃.

Thank you Danielle Gerhard and The Scientist for highlighting our research on editing #RNA with #CRISPR! Grateful for the opportunity to share our work with a wider audience🔥🔥 Check out the article here ⬇️⬇️⬇️

Online Now: Type III CRISPR-mediated flexible RNA excision with engineered guide RNAs dlvr.it/TJ48Hs