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#apaperaday from home with Yuzu refusing to pose properly. Today's pick is from PLOS One by Woodcock et al on a phase 2 trial in non ambulant patients with Duchenne with an antisense oligonucleotide ATL1102 with ant-inflammatory properties DOI: 10.1371/journal.pone.0294847

First authors report on a study in the mdx mouse model. They used males, included wild type controls and also compared to a scrambled ASO and 12 mice per group. Hooray so far. However, when doing the analysis authors compared to saline rather than scrambled control 👇🫤

This is a very nice research group in Biogipuzkoa searching for a postdoc.... Could you RT? #sciencejobs #postdoc

New paper from the lab in Nucleic Acid Therapeutics Oligonucleotide Therapeutics Society journal, in collaboration with Brage Storstein Andresen 👇👇👇 Antisense oligonucleotides as potential therapy for PKU splice variants COST DARTER @CBMSeveroOchoa CIBERER CEDEM #PKU #AON #CRISPR

The NINDS Office of Research Quality workshop on “Novel Approaches to Preventing Publication Bias” is less than one month away! You may register for online viewing to get the videocast link on your calendar! forms.roseliassociates.com/view.php?id=98…

As you know, I think we should try to publish all good research, even when the results are not what we expected, or not sexy enough for a "high impact" publication, so I am very excited to participate in this meeting:

On my way to Università di Trento for a PhD viva tomorrow... Looking forward finally return the visit to Prof Dr Michela A Denti and seeing @roon_mom in 3D and Aurelie Goyenvalle in 2D... Nice things you still reap from COST Action COST DARTER. #sciencetwitter #academia

Being in a room packed with other researchers interested in publishing "negative" results, Open Science and research integrity for two days... I'm enjoying it so much only some COST DARTER members would understand... (Hey, we are not alone)...

Shalini Andersson from AstraZeneca is giving the keynote lecture, which is masterclass on #antisense #oligonucleotides at the #DATS2024, highlighting one of the greatest efforts of COST DARTER! You can find this fogure: embopress.org/doi/full/10.15…

Alex Garanto AstraZeneca COST DARTER Ronald Buijsen @roon_mom AnnemiekeAartsma-Rus Lourdes Ruiz Desviat Aurelie Goyenvalle Prof Dr Michela A Denti Rob Collin Dutch Antisense Therapeutics Love it when people use our work.... this is why we did it!

The oligo field is rapidly moving forward! #OTS24

Maire Fiona Jung discussed one of the most important aspects in the field, delivery. She shows promising data for delivery of ASOs to other tissues then the liver! #OTS24

Be Part of OTS History! Contribute to the 2024 Video Time Capsule To celebrate the 20th Annual Meeting, the Oligonucleotide Therapeutic Society is creating a video time capsule, and we want YOU to be a part of it! #ots #oligotherapeutics #oligonucleotide #biotech #biotechnology

Join our Team! The Nucleic Acid Therapeutics in Rare Diseases (NAT-RD) Group IIS Biobizkaia is looking for researchers! 🧬 #WMS2024 #OTS24 Several positions 👇👇

Our review on RNA therapies for urea cicle disorders is now online! #RareDiseases 👇👇 COST DARTER Eva Richard Centro de Biología Molecular Severo Ochoa CIBERER UAM Autónoma Madrid

Thanks thanks thanks to Fundación ”la Caixa” for its commitment to science and … for seeing how amazing our project is! Thanks to Oscar Llorca and F. Moreno-Herrero for this journey!

#apaperaday Today's pick is from Journal of Cystic Fibrosis by Caraco et al on a clinical trial in healthy volunteers to test safety and tolerability of inhalation of an cryptic splicing restoring antisense oligonucleotide (ASO) for cystic fibrosis DOI: 10.1016/j.jcf.2024.10.004

🧬 El sábado hablé en #NaukasValladolid sobre #terapias de ácidos nucleicos para #enfermedadesraras. 🌟 Es el nombre y la misión de mi grupo de investigación en IIS Biobizkaia , y en esta charla intenté explicar nuestra visión y el futuro de este campo. 👇

Si os interesa, podéis ver la charla completa aquí: "ADN y ARN: descifrando los códigos de la enfermedad y el tratamiento" ➡️ youtu.be/YQPpXOtcdVo?si…

🧬Las células tumorales pueden reparar los daños en su material genético causados por la quimioterapia y la radioterapia, lo que les permite generar resistencia a los tratamientos. Con una ayuda #CaixaResearch, Puri Fortes estudiará estos mecanismos en los cánceres de