🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

New paper from the lab! ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes: cell.com/cell-reports/f… #ALS

nature.com/articles/s4158… Excited to share new work form our lab led by Shinya Imada and Saleh Kwaled Saleh Khawaled, PhD demonstrating how a post-fast refeeding drives stem cell mediated regeneration via polyamine metabolites. The work would not have been possible without our great

In our new study we reveal how NAC coordinates and regulates successive co-translational nascent chain ⛓️ processing on the mammalian ribosome out today in nature rdcu.be/dRAQY collab with Deuerling Lab Shu-ou Shan Caltech Swiss National Science Foundation European Research Council (ERC) ETH Zurich

📢Last call for registration - which will end on 31 Aug. 2024. Registration 👉 indico.leibniz-fli.de/event/2/ Take your chance to be part of it! 😊 #conference #microbiome #aging #scientists

Good news: a team of #scientists led by Dr. Björn von Eyss who heads the research group "Transcriptional Control of Tissue Homeostasis" at Leibniz-Institut für Alternsforschung (FLI) has discovered an additional control mechanism that prevents the growth of #liver #cancer. 👉More: bit.ly/3TwkpP1

Our paper on the evolution of structural variation at the amylase locus is out today in Nature! nature.com/articles/s4158… congrats to co-first authors Joana L. Rocha Nicolas Lou Davide Bolognini Alessandro Raveane & Alma Halgren, co-corresponding author Erik Garrison

Did you know that nuclear pore complexes can turn up outside the nuclear envelope? Studying these, Jenny Sachweh, Bernhard Hampoelz and others uncover that the surrounding cellular milieu determines NPC composition via the nuclear transport system itself. #teamtomo #NPC A 🧵

Cytoplasmic nuclear pore complexes 🤯Beck Laboratory 👏👏

I am thrilled to announce that our work in collaboration with Alessandro Ori’s lab Alessandro Ori, @Blue_ceil is out! We made a significant breakthrough in understanding the role of lysosomes in the brain with the development of the first cell-type-resolved lysosomal protein atlas.

🚨New Paper Alert🚨Explore our latest work on the Lysosomal BrainAtlas, now available on bioRxiv! This comprehensive resource maps lysosomal proteins in specific brain cell types and identifies SLC45A1 as a novel neuron-specific lysosomal sugar transporter doi.org/10.1101/2024.1…

Thrilled to share the most comprehensive Atlas of Proteome/Phosphoproteome Turnover across mouse tissues and brain regions, thanks to the outstanding Yansheng Liu & Junmin Peng! Proud to contribute to this. Check it out: #Proteomics #ProteinTurnover biorxiv.org/content/10.110…

1. Check out our MS just out! Amazing Mauricio Aguilar developed a new ML pipeline that identifies ribosome pausing sites as an Anomaly Detection problem to overcome spurious signals that arise when analyzing RiboSeq data. science.org/doi/10.1126/sc…

Brain responses to intermittent fasting and the healthy living diet in older adults cell.com/cell-metabolis…

Our new paper from the Frydman Lab published in Science Magazine identifies 22 TRiC mutations in patients with brain disorders of unknown origin. We characterized these disease-linked mutations in 3 model species and found them to be dominant mutations. science.org/doi/10.1126/sc…

Are you a metabolomics expert seeking new opportunities for professional growth and discovery? come join us Molecular Therapeutics Initiative!

🚨🚨Mark your calendars for G-JAM2025 meeting organised be me and Sandro Cellerino. We will discuss human aging, longevity interventions, molecular and systems aging, comparative biology of aging, sex-specific aspects of aging and more. Looking forward! leibniz-fli.de/news-events/co…

We are very excited to share our recent preprint on the nuclear import mechanism of the proteasome, driven by the multivalent adaptor AKIRIN2! biorxiv.org/content/10.110… 🧵 (1/7)

Check out our MS describing the in vivo cycle of chaperonin TRiC/CCT, in a wonderful collaboration with Martin Beck's lab: nature.com/articles/s4158… 1) The study established TRiC's important function in folding newly translated proteins and defines its ATP-driven cycle

Can one become too old for healthy aging? In our recent review, we explore possible age limitations of the current longevity treatments. nature.com/articles/s4432…