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Heterozygous mutations in the gene encoding RagD GTPase have been identified as the cause of this unique autosomal dominant condition! shorturl.at/TUVX7

Have you been thinking of CRISPR-screen and genetics in complicated diseases? By leveraging direct variant insertion and single-cell sequencing, the researchers explore the impact of noncoding variants on gene expression and regulatory networks. tinyurl.com/zb79wwhr

Dive in this beautiful review article about diabetic kidney disease talking about the molecular and genetic studies highlight the critical role of podocytes and endothelial cells in driving albuminuria and early kidney disease in diabetes. tinyurl.com/yfhnpncz

APS ETG APS ETG members: Call for papers in AJP Renal on diabetic kidney disease, guest associate editors Sandeep K. Mallipattu and Dr Kyung Lee journals.physiology.org/ajprenal/diabe…

Do you use two-photon microscopy for your research? Check out the recent development of the Synthetic Aperture Radar in Two-Photon Microscopy (SAR-TPM)! tinyurl.com/3z8wpd72

Check out this review on human pluripotent-stem-cell-derived organoids! tinyurl.com/3kbbc889

Dive into the fascinating world of precision medicine as scientists unlock the potential of alpha-methyl-4-deoxy-4-[18F]fluoro-D-glucopyranoside (Me4FDG) as a predictive tool. tinyurl.com/3ywuh35w #APS #diabetes #MRI #petscan

Check out this study uncovering 30 previously unidentified CpG sites significantly linked to baseline eGFR and all previously unidentified eight CpG sites associated with eGFR slope! tinyurl.com/58fd5hex #APS #epigenetics #diabetes #KidneyDisease

How is the MCT4 transporter-dependent lactate secretion is involved in immunotherapy resistance in KRAS-mutated lung adenocarcinoma? Dive in this new research! pubmed.ncbi.nlm.nih.gov/37327788/ #APS #APSETG #lungcancer #Lactase #cancerimmunotherapy

Do you perform tissue fixation in your lab on a daily basis? Check out this new formalin alternative and let us know what you think! pubmed.ncbi.nlm.nih.gov/37321542/ #APS #APSETG #histology

Check out this paper utilizing single cell barcode-based lineage tracing (CellTagging) and organoids to identify and functionally assess a new regionally distinct cell population in human developing lungs! pnas.org/doi/epdf/10.10… #APS #APSETG #singlecell #organoids

Friday is for learning! Dive into this fascinating review on cystic fibrosis in JAMA! pubmed.ncbi.nlm.nih.gov/37278811/ #APS #APSETG #cysticfibrosis

Which CFTR mutation response well to the "correctors"? Check out this study uses deep mutational scanning and reveals that specific mutations have the greatest sensitivity to the correctors. pubmed.ncbi.nlm.nih.gov/37253358/ #APS #APSETG #cysticfibrosis #genetics

Friday is for learning!! Have you used the air-liquid interface cultures in your lab? pubmed.ncbi.nlm.nih.gov/37196698/ #APS #APSETG #drugdelivery

Check out this research reveals the role of the YAP pathway in regulating activator protein-1 expression in renal tubular cells, shedding light on the underlying mechanisms of tubular injury, inflammation, and fibrosis. pubmed.ncbi.nlm.nih.gov/37141146/ #APS #APSETG #chronickidneydisease

The latest study discovered the crucial role of IRAP (insulin-regulated aminopeptidase) in water excretion and the regulation of aquaporin 2 (AQP2) expression. pubmed.ncbi.nlm.nih.gov/36995926/ #APS #APSETG #Kidney #renaldisease

WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release. Let's have a look ! jci.org/articles/view/…

Jens Leipziger and his collaborators showed recently that the loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion and Aggravates Metabolic Alkalosis in Mice during Acute Base-Loading : Journal of the American Society of Nephrology journals.lww.com/jasn/Abstract/…

Lama Al-Qusairi et al. demonstrated that Dietary Anions Control Potassium Excretion; it is More Than a Poorly Absorbable Anion Effect | American Journal of Physiology-Renal Physiology journals.physiology.org/doi/abs/10.115…

If you wanna get familiar with the thiazide sensitive Na+-Cl− cotransporter check this fresh review of G. Gamba ! Thirty years of the NCC cotransporter: from cloning to physiology and structure | American Journal of Physiology-Renal Physiology journals.physiology.org/doi/abs/10.115…