After decades-long struggles with microRNA-based therapeutics, Regulus hits paydirt in the clinic and in the marketplace. Is it the beginning of a trend or a one-off? nature.com/articles/s4158…

Genetic and chromatin regulation of Pvt1 monoallelic expression dlvr.it/TPCYvS

We are pleased to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in nature. Please check out our manuscript here: nature.com/articles/s4158….

🚀 Excited to share our preprint scConcept: a contrastive pretraining framework for technology-agnostic single-cell representations. We move beyond reconstruction to learn rich, cell-level embeddings for diverse omics. 📘 biorxiv.org/content/10.110…

Online Now: High-throughput capture of actively transcribed region-interacting sequences reveals an intricate promoter-centered regulatory network dlvr.it/TPKvxs

Happy to share #DNALONGBENCH Nature Communications. We challenge DNA #FoundationModels w/ long-range sequence context and hope this sparks more meaningful ways to evaluate growing AI+BIO models. Kudos to Wenduo Cheng Zhenqiao Song Yang Zhang. Great collab w/ Lei Li @NeurIPS2025. nature.com/articles/s4146…

FDA approves new mechanism to treat idiopathic pulmonary fibrosis, expanding limited arsenal nature.com/articles/s4158…

We found that most published RNAseq studies may be underpowered: Optimized murine sample sizes for RNAsequencing studies revealed from large scale comparative analysis nature.com/articles/s4146…

Our paper is out in nature! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11 nature.com/articles/s4158…

Nature research paper: Genetic elements promote retention of extrachromosomal DNA in cancer cells go.nature.com/4pkUpDE

In Brief: uniQure's AMT-130, a one-off microRNA gene therapy administered directly into the brain, has met its primary endpoint in a phase 1/2 study, slowing Huntington disease progression by 75% nature.com/articles/s4158… rdcu.be/ePM4Y

Ever wanted to do a genome-scale CRISPR screen for a microscopy-based phenotype? Pooled CRISPR screens are amazing, but hard to combine with microscopy... Excited to share a technology platform for such imaging screens and applications to primary cilia... cell.com/developmental-…

Excited to introduce CRISPR-All! – a flexible, high-throughput framework that combines virtually any perturbation modality (CRISPRko, CRISPRi, CRISPRa, shRNA, knock-in, base/prime editing, etc.) in the same cell, at scale. Paired with single-cell RNA-seq 10x Genomics and rich

How circular extrachromosomal DNA is inherited during cell division has been a puzzle go.nature.com/43FURny

Epigenetics Update - Addressing the specific roles of histone modifications in transcriptional repression go.nature.com/4pqQXXQ Kristian Helin reporting in Nat Commun #Epigenetics #HisMods #Chromatin --- Discover the breakthrough at epigenometech.com

Nature research paper: Prime editing-installed suppressor tRNAs for disease-agnostic genome editing go.nature.com/3XKEHpj

.Mayo Clinic scientists demonstrate that genetic loss of protein kinase Cι alters the trajectory of mouse Kras/Trp53-driven #LUAD tumors from one resembling lung development to one mimicking lung regeneration. 🫁 bit.ly/44wpeNo

Is fibroblast proliferation important in pulmonary fibrosis? Finally an answer - great paper by the super team of Christopher Molina,Tatsuya Tsukui, and Dean Sheppard #זScienceMatters #CureIPF jci.org/articles/view/…

latest from the lab --> how we used whole genome passenger somatic mutation patterns 🧬 to trace the origins of never-smoker lung adenocarcinoma (LUAD) to cells of the proximal lung 🫁 Nature Genetics nature.com/articles/s4158… 1/🧵

Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors go.nature.com/4f7daor rdcu.be/eRy1T