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Mitochondrial dysfunction in CNS manifests with neurodegeneration and reactive gliosis, traditionally explained by vulnerability of [their majesty] neurons. We thought it may not be the full story... and found critical astrocyte contribution to the pathology! 🤓 1/

Our January cover shows a scanning electron microscopy micrograph of ependymal cells lining the surface of a mouse brain ventricle. From Olesia Ignatenko et al Anu Suomalainen-Wartiovaara Lab (bit.ly/3hKkL4D). Read JCB’s January Issue: bit.ly/3BXac5c

Very excited to follow the entry of the 1-yr-old startup NADMED to USA market via partnering with TruDiagnostic. NADMED is an innovation that was initiated in my Anu Suomalainen-Wartiovaara Lab developed by docent Liliya Euro. prnewswire.com/news-releases/…

Being a scientist is the best job. When the lab becomes silent on Friday evenings, the ideas from the past week start to get together and bubble. Alone in the office, content and energized. So happy to work with you all Anu Suomalainen-Wartiovaara Lab!

#WorldMitoWeek is upon us! Rohit Verma joins us to explore the intricacies of mitochondrial disorders, patients' daily challenges, and treatments to manage these conditions. SoundCloud bit.ly/3EHDQMJ Spotify bit.ly/3ZmdARC ApplePod bit.ly/3Zjl4EZ

For the #WorldMitoWeek Anu Suomalainen-Wartiovaara Lab Henna Tyynismaa and @FhrcGracile are organizing an open doors day, with scientists, patients & families, doctors and Neuroliitto ry patient union talks. 21.9. at 15-18 EET. In Finnish, translated to English in zoom. Follow link: helsinki.fi/en/researchgro…

Mitä ovat mitokondriotaudit? #WorldMitoWeek avoimien ovien MitoPäivä Biomedicumissa, 21.9. klo 15-18. Tule tutustumaan mitokondriotauteihin ja niiden tutkimukseen, potilaiden ja perheen kertomuksiin, kuulemaan lääkärien ja Neuroliitto ry asiantuntemusta. helsinki.fi/fi/tutkimusryh…

Join us for Mitochondrial Disease Open Doors on Thursday 21 Sept at 15:00 (GMT+2) on site or remote! Further details: helsinki.fi/en/researchgro… #WorldMitoWeek #LightUpForMito

Tule mukaan avoimien ovien MitoPäivään torstaina 21.9. klo 15:00 alkaen Biomedicumissa ja webinaarissa. Lisätietoja: helsinki.fi/fi/tutkimusryh… #WorldMitoWeek #LightUpForMito

Tänään Medicine and Health, University of Helsinki mitokondriotautipäivä, Biomedicum Helsinki ja zoom. Lauantaina vihreät rakennukset Australiasta Suomeen ja Amerikan mantereelle muistuttavat potilaiden viestistä: toivo on tutkimuksessa. University of Helsinki

Thank you JCB for selecting our article on metabolic ciliopathy of astrocytes as one of the 10 highlights of 2023 in the journal’s special issue ”Year in Cell Biology” Olesia Ignatenko Gulayse Ince Dunn Medicine and Health, University of Helsinki University of Helsinki STEMM Research Program Anu Suomalainen-Wartiovaara Lab HiLIFE_Helsinki

Metabolism Seminar time again next week March 26th at 9-11 in Biomedicum. Exciting talks from Öörni_Lab and Anu Suomalainen-Wartiovaara Lab on lipoproteins, atherosclerosis, mitochondrial disease and mtDNA replication ☕️🍪at 8:30,Welcome! Medicine and Health, University of Helsinki STEMM Research Program Life Sciences University of Helsinki HiLIFE_Helsinki

Very happy to share our new article of the interaction of mitochondria, innate immunity and viral infections and the relevance for brain &liver disease. Impressive work by Yilin Kang. Thanks Jussi Hepojoki Olli_Vapalahti and all collabs! University of Helsinki Anu Suomalainen-Wartiovaara Lab rdcu.be/dDx2G

High mtDNA replication frequency is deleterious for newborn heart, causing dilated cardiomyopathy & ferroptosis. Our paper out in Nature Communications, outstanding work by Juan Cruz Landoni. Thanks for crucial results Semin Erkul Anu Suomalainen-Wartiovaara Lab Medicine and Health, University of Helsinki University of Helsinki nature.com/articles/s4146…

Fantastic work and exciting findings by Juan Cruz Landoni and Anu Suomalainen-Wartiovaara Lab👇

PolG Foundation tukee mitokondriosairauksien tutkimusta. Säätiön lyhytfilmi kuvaa koskettavasti kuinka sairaus vaikuttaa potilaisiin ja heidän läheisiinsä. (Video vain englanniksi) The PolG Foundation Film youtu.be/Oh-a_EKgp_Y?si… via YouTube

The PolG Foundation supports mitochondrial disease research. The Foundation's short film describes how the disease affects the lives of patients and their families. The PolG Foundation Film youtu.be/Oh-a_EKgp_Y?si… via YouTube

ASWlab's Rohit Verma & Anastasiia Marmyleva together with Dr. Eleanna Asvestari talk about #mito in research and patient care in The Science Basement Podcast podcast episode: open.spotify.com/episode/3JvdPR… #lightupformito

Time for a short explicative 🧵 for the busy 🐝! In our new report (#OA: rdcu.be/dTXcm) we found that enhancing #mtDNA replication can be deleterious for newborn #heart, causing dilated #cardiomyopathy & #ferroptosis 🫀 (1/6)

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024.1…), and Gabriel (Gav) Sturm et al. dissect the biophysics behind it (doi.org/10.1101/2024.1…). Details below! 🔬🧵