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Interesting study. Patients with moderate to severe ARDS required less sedatives under a pressure-controlled mode with spontaneous breathing, compared to a volume-controlled mode without spontaneous breathing. Strangely, the PC patients could not be weaned earlier.

The inflamed lung is full of immune cells, but how do they get there? We found that immune cells can generate large traction forces - comparable to fibroblasts - that help them migrate through narrow pores. Read more in Nature Physics: rdcu.be/dU9Nj

New on medRxiv! “How to minimize mechanical power during mechanical ventilation” For any given V'min, a tidal volume of twice the anatomic dead space (~4.4 ml/kg in adults) always minimizes elastic mechanical power (the energy needed for lung expansion). medrxiv.org/content/10.110…

I have moved to Bluesky (bsky.app/profile/atc-ve…) and hope my Twitter friends will join me there soon. While I may check in on Twitter occasionally, my primary activity will be on Bluesky. Looking forward to reconnecting there! Ariel J Garnero Doc Musician VentBusters Sameed M

Today, I tested the Dräger Evita V600 ventilator in CPAP and ATC mode with a lung simulator. CPAP worked well, but in ATC mode, the V600 compensates only 25% of the total tube resistance, and that is possibly not enough to make a difference for patients.

How does a commercial ventilator (Dräger V600) in ATC mode compare to my 3-D printed ATC ventilator? Poorly, I would say, but judge for yourself. I am convinced that weaning can be greatly improved and shortened with real ATC. youtu.be/Y4To7-krE14

The flow limitation imposed by the endotracheal tube is a major cause of weaning failure, patient-ventilator desynchronization, and PSILI. During bronchoscopy, the tube resistance becomes prohibitive. Check out our paper medrxiv.org/cgi/content/sh…

We developed a browser-based tool to predict ventilation impairments such as iPEEP buildup, hypoventilation, and desynchronization due to the tube resistance (also during bronchoscopy). Check it out: fabrylab.github.io/Bronchoscopy/