🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Virus-free continuous directed evolution in human cells using somatic hypermutation biorxiv.org/cgi/content/sh… #biorxiv_synbio

The Mammalian Synthetic Biology Workshop (#mSBW2025) is coming Aug 11 & 12 2025 at UC Irvine.

🚨NEW PUBLICATION ALERT🚨: In a paper out today in Science Magazine we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/sc…. 🧵1/n

Genetic and materials engineering to enhance inducible gene expression in lactobacilli biorxiv.org/cgi/content/sh… #biorxiv_bioeng

Preprint alert! We designed synthetic promoters to respond to transcription factors differentially expressed in functional and exhausted T cells showing broad strength of activation. biorxiv.org/content/10.110…

Gene syntax defines supercoiling-mediated transcriptional feedback biorxiv.org/cgi/content/sh… #biorxiv_synbio

🚨Have you ever wondered how the order and orientation of two transgenes impact transcription and gene circuit performance? Check out the latest preprint from Katie Galloway !

🔥New Fraticelli lab publication🔥 “Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations” Two new figures compared to the pre-print, with more in vivo and sequential mutagenesis data. sciencedirect.com/science/articl…

Come join us for Systems Biology of Single Cells 2025, taking place May 8-9, 2025 at UC Irvine, California. (link and more info in thread below)

Today at Cell Systems we report in back-to-back papers (!) led by Nat B. Wang 🧬🧑🏻‍🔬🏳️‍🌈 on how cell state potentiates the influence of individual transcription factors to drive cell-fate programming & how we used these insights to scale up production of motor neurons from primary

Need a site-specific, dox-inducible system for human cells? Low leakage, silencing-resistant, and modular? It’s here in the first paper from my lab, led by Tomoki Yanagi MD, PhD. Bonus: forward programming of TEC-like cells from hiPSCs. tinyurl.com/trunod01

REGISTER NOW! 🚨🚨 Spots are filling up for the first EMBO workshop on Single cell Lineage Tracing 2025!! Sept 18-21 in Girona, Spain. Tons of opportunities for talks (short and full length) still available!!! meetings.embo.org/event/25-linea…

Dr.A.Blanch-Asensio🎓 Thrilled to share that I’ve successfully defended my PhD on advanced synthetic biology tools for stem cell engineering. >5+ years, we developed STRAIGHT-IN, a versatile platform for precise DNA integration in hiPSCs. Grateful for this incredible journey! 🧬

Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in nature. This has been an amazing collaboration with the lab of Lars Velten (@larsplus) at Centre for Genomic Regulation (CRG) nature.com/articles/s4158…

Finally out in Nature our collaboration with the Velten Lab 🥰 Enjoy the reading! nature.com/articles/s4158…

In the latest issue! Fate and state transitions during human blood vessel organoid development dlvr.it/TLLPTf

Delighted to bring gene circuits into a wide array of primary cells where they can be used for safe, effective gene therapies. 🧵 (1/n) Tremendous work by lead author Kasey Love to dig into the details of these systems and figure out how to get these to work well! Original

Katie Galloway, PhD, Katie Galloway at MIT ChemE Dept and her project titled, “Search and rescue: engineering targeted cell delivery for repair of the central nervous system” vimeo.com/1092614013/168…

So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein