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How do distant DNA loci come into contact to activate genes? Our paper combining live imaging 🔬& polymer physics 🧬 to answer this is out in Science Magazine! We show how chromosome packing & diffusion determine pairwise dynamics & transcription 👉science.org/doi/10.1126/sc… 1/n

Last week was a week full of great science and great people at the MPS World Summit 2023 conference! My highlight was presenting my work on an iPSC-derived Intestine-Chip system and sharing this moment with Joram Mooiweer, who presented his work on organoid-T cell co-cultures.

Gateway to Building Connections and Launching a Career in Synthetic Biology: Porfirio's iGEM Journey Read about Porfirio's experience after iGEM and his advice on building a career on our blog community.igem.org/20th-year-of-i… #20thYearofiGEM

10 Questions with Trishla Sinha - Trishla Sinha from the Netherlands is an MD/Ph.D. student at UMCG, Netherlands & #LINO23 participant. Enjoy Ulrike Boehm 🔬👩🏻‍💻's interview with her & get inspired Lindau Nobel Laureate Meetings #womeninscience 🥳👉 womeninresearchblog.wordpress.com/2023/07/16/tri…

We made a small intestine-on-chip from cells isolated from urine! It’s out: In our preprint we highlight the remarkable self-organization of human iPSC-derived intestinal epithelial, mesenchymal and neural cells in an intestine-on-chip system. biorxiv.org/content/10.110… More info👇

Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation - a review by @HausmannAnnika, Kim Jensen reNEW, Ole H. Nielsen & Casper Steenholdt Trends in Molecular Medicine #AAI2024 hubs.li/Q02vSqgF0

Xist ribonucleoproteins promote female sex-biased autoimmunity. Check out this collaboration b/w Stanford University Howard Chang, Diana Dou and others in Cell #AAI2024 hubs.ly/Q02vSxG40

A new superhero, the intraepithelial mast cell, joins the “Guardians of the Gut” dlvr.it/T73rwm

The importance of stupidity in scientific research

Train PhD students to be thinkers not just specialists

Why Study Multiple Sclerosis? Studying autoimmunity helps to improve lives. #MultipleSclerosis teaches us not just about its own nature but also about the interconnectedness of genetics, environment, and health. 💡 Curious to know more? Look at my post: aarondrs.com/posts/post2.ht…

CRISPR screen of >6,200 lnRNAs across 5 cell lines prioritizes 46 universally essential and >700 context-specific essential lncRNAs sciencedirect.com/science/articl…

This MIT class is still the best way to learn Linear Algebra. It's free. Gilbert Strang is one of those generational professors. The type of person that will leave a positive mark on you. ocw.mit.edu/courses/18-06-…

Thrilled to introduce a new single-cell 3D genome analysis tool to our toolkit! Our high-throughput droplet Hi-C (dscHi-C) and dscHi-C-multiome methods use droplet microfluidics to generate tens of thousands of single-cell Hi-C profiles with high sensitivity in a single batch.

Mike Love's response: x.com/mikelove/statu…

Very happy to release the single cell and spatial long read RNA seq module for our transcript discovery and quantification tool Bambu (Bambu-clump)! The key challenges were dimensionality and accurate estimation of transcript expression with minimal data biorxiv.org/content/10.110…

Biomolecular condensates: It was RNA all along!: Molecular Cell cell.com/molecular-cell…

RNA polymerase II coordinates histone deacetylation at active promoters science.org/doi/10.1126/sc…

xOmicsShiny: an R shiny application for cross-omics data analysis and pathway mapping biorxiv.org/content/10.110… #Rstats 🧬🖥️🧪 github.com/interactiverep…

Biological systems find ingenuous solutions. Almost anything that can happen, happens. Still, I would not have guessed a role of RNA-binding proteins on the cell surface. The Flynn lab are boldly investigating glycoRNAs and following their leads.