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Excited to share our new work on next-gen mRNA therapeutics led by talented Abhi Aditham and Hailing Shi. We developed mRNA-oligonucleotide conjugated RNA (mocRNA) to stabilize RNA and boost protein expression in mammalian cells. pubs.acs.org/doi/10.1021/ac…

Congratulations on this beautiful work, Xiao Wang!

Branched chemically modified poly(A) tails enhance the translation capacity of mRNA go.nature.com/3PzhhzM

Why can RNA only be linear or circular? It can be branched! We made multi-tailed mRNA, and we had fun! Here is our story led by brilliant graduate student Hongyu Chen: rdcu.be/dB7ck and his cartoon illustration👇MIT Chemistry Broad Institute

.Xiao Wang has engineered mRNAs that have higher levels in cells, last longer in animals, and could potentially be used as long-lasting treatments that edit genes or replace faulty proteins. broad.io/mRNApolyAtail

An exciting new report in Nature Biotechnology from Xiao Wang’s team led by Hongyu Chen shows that mRNAs with branched poly-A tails yield much higher levels, and prolonged production, of the corresponding proteins compared with conventional single-tailed mRNA. This discovery

Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation go.nature.com/47EXbfq

Synthesizing RNA can be as fun as LEGO puzzles! This work is co-led by my incredible colleagues Dangliang Liu and Abhi Aditham . Huge thanks to my supervisor Xiao Wang for such amazing ideas. We are also grateful for the editor, reviewers, and all collaborators along the way.

Chapter 2 of branched RNA: chemically modified branched cap for multi-capped mRNA and capped circular RNA (QRNA)--the cellular translation machinery is surprisingly tolerant of unnatural structures! Beyond enhanced performance, the mechanism is intriguing: rdcu.be/dUQKX

MIT Chemistry Broad Institute MIT Dept of BE HHMI McGovern Institute MassGeneral Medicine MIT Brain and Cognitive Sciences Xiao Wang Hongyu Chen Dangliang Liu New approach may yield modified messenger RNAs for treating a wide range of conditions #NBTintheNews via Broad Institute broadinstitute.org/news/multi-cap…