Structure of a human 48S translational initiation complex science.sciencemag.org/content/369/65…

Excited to announce that I am establishing my group at WEHI (Walter and Eliza Hall Institute) early next year! I am so grateful to my mentors Lori Passmore and Sarah Butcher for shaping my scientific career. Please contact me if you are interested in joining us to study multi-protein complexes by #CryoEM.

Structural basis of ribosomal frameshifting in SARS-CoV-2. Stimulatory viral RNA pseudoknot lodges at mRNA entrance channel, priming the ribosome to change the reading frame. Collaboration with Bode Group, Volker Thiel, and Atkins labs.disq.us/t/3si8nus

Check out the new paper on the ASCC3 NTR bound to ASCC2.

Excited to have contributed, together with Markus C. Wahl, to the second edition of "RNA Remodeling Proteins". Our work on the spliceosomal RNA helicase Brr2 can be found here: link.springer.com/protocol/10.10…

Fancwell Shabih!

Yesterday, the German Society for Crystallography (DGK) awarded Manfred Weiss Manfred S. Weiss with the Will-Kleber Medal 2021 for his methododological developments in crystallogrpahy. Congratulations. @HZB BESSY@HZB

In a new Science study, researchers present #RoseTTAFold—an #AI network that produces structure predictions with accuracies approaching those of DeepMind’s AlphaFold2. The tool’s code is freely available. Read more: fcld.ly/xgy73r8

I am very happy to share our work with Torben Heick Jensen and Andrzej Dziembowski labs on how the length of poly(A) tails is determined. @MRC_LMB European Research Council (ERC)

👇I can look at this forever!

We solved a long-standing question about the precise role of the NSUN4 RNA methyltransferase in mitochondria. A fantastic collaboration between @BurtonNick Eric Miska Lab from the Gurdon Institute and the Venki Ramakrishnan group @MRC_LMB nirupa desai Hanting Yang (杨涵婷)

PolyA tails on eukaryotic mRNAs are added after co-transcriptional endonucleolytic cleavage of the pre-mRNA. Vytaute Boreikaite has now reconstituted specific and efficient 3ʹ-endonuclease activity by human CPSF with purified proteins. European Research Council (ERC) @MRC_LMB biorxiv.org/content/10.110…

New work led by Eva Absmeier and Vish Chandrasekaran shows how human CCR4-NOT recognises slow-moving ribosomes in codon-optimality decay. Francis O'Reilly Rappsilber laboratory European Research Council (ERC) @MRC_LMB

New work from Manuel Carminati shows that dephosphorylation of RNA polymerase II by CPF (the 3' end processing machinery) promotes Pol II dimerisation. Cemre Manav @MRC_LMB European Research Council (ERC)

Thus, Pol II dimerisation may provide a mechanistic explanation of the allosteric model of termination!

come to Wonderful Copenhagen - 5th year in a row of this great symposium rotating in the CryoNET network (Copenhagen, Aarhus, Umeå, Stockholm)

If you agree that ERC should remove their academic age limits on ERC grants - please Sign this Petition! Please also RT: #EDI #science #EuropeanScience #ERCgrant chng.it/zvm4fDmFdj via Change.org UK

Very fun collaboration and I am very happy to have worked with Markus Höpfler on tubulin auto-regulation!

We usually think of mRNAs carrying the information needed to make a protein (the central dogma...). But how can the encoded protein control the fate of its encoding mRNA? 🤔 Check out our review on the topic 👇 cell.com/molecular-cell…