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Article✍️Targeting #copper #homeostasis: #Akkermansia-derived #OMVs co-deliver #Atox1 #siRNA and #elesclomol for #cancer #therapy. From Dr. Zhou @ZhengzhouUniversity; Elsevier Pharma. sciencedirect.com/science/articl….

Article✍️#Metabolic #reprogramming #nanomedicine potentiates #colon #cancer #sonodynamic #immunotherapy by inhibiting the #CD39/#CD73/#ADO pathway. From Dr. Zhang @Xi’anJiaotongUniversity; Elsevier Pharma. sciencedirect.com/science/articl….

Article✍️#Sulfafurazole #dimers potentiate #chemo-#immunotherapy of low #immunogenic #breast #cancer by preventing the #PD-#L1 #exosomes secretion. From Dr. Sun @ChinaPharmaceuticalUniversity; Elsevier Pharma. sciencedirect.com/science/articl….

Article✍️#Celastrol-#loaded #ginsenoside #Rg3 #liposomes boost #immunotherapy by remodeling #obesity-related #immunosuppressive #tumor #microenvironment in #melanoma. From Dr. Xiong @ZhejiangChineseMedicalUniversity; Elsevier Pharma. sciencedirect.com/science/articl….

Article✍️A #cisplatin #prodrug-based self-#assembling #ozone delivery #nanosystem #sensitizes #radiotherapy in triple-negative #breast #cancer. From Dr. Shi @SichuanUniversity; Elsevier Pharma. sciencedirect.com/science/articl….

Article✍️#Phenotypic #plasticity and secretory #heterogeneity in subpopulations derived from #single #cancer #cell. From Dr. Wu Sun Yat Sen-senUniversity; Dr. HU Tulane University; Tulane Medicine; Elsevier Pharma. sciencedirect.com/science/articl….

Article✍️#Imaging the impact of #sex and #age on #OATP function in humans: Consequences for whole-body #pharmacokinetics and #liver #exposure. From Dr. Nicolas Tournier Université Paris-Saclay; Elsevier Pharma. sciencedirect.com/science/articl….

Article✍️#Prodrug-based #combinational #nanomedicine remodels #lipid #metabolism for reinforced #ferroptosis and #immune #activation. From Dr. Jing @SichuanUniversity; Elsevier Pharma. sciencedirect.com/science/articl….

Article✍️#Marine-derived new #peptaibols with #antibacterial activities by targeting #bacterial #membrane #phospholipids. From Dr. Lin @PekingUniversity; Elsevier Pharma. sciencedirect.com/science/articl….

Letter to Editor✍️#Design and #functional characterization of a #tetravalent #NK cell-engaging #bispecific #antibody with enhanced half-life for #CD30+ #lymphoma. From Dr. HU Fudan University; Elsevier Pharma. sciencedirect.com/science/articl….

Letter to Editor✍️#Targeting #stiff #stroma by neutralizing #LOX-mediated matrix crosslinking in #pancreatic #cancer. From Dr. Jiang ShanghaiJiaoTongUniv; Elsevier Pharma. sciencedirect.com/science/articl….

Letter to Editor✍️#SMAD4 #depletion enhances #NHEJ by regulating #BRCA1 expression through #ARIH1 in #pancreatic #cancer. From Dr. Wang Fudan University; Fudan University; Elsevier Pharma. sciencedirect.com/science/articl….

Highlight🧐#Extrachromosomal #DNA as a carrier of extra copies of #oncogenes for #heterogeneity and malignancy of #glioma. From Dr. Ye @ZhengzhouUniversity; Elsevier Pharma. sciencedirect.com/science/articl….

Video Abstract📺Dual activation of #GCGR/#GLP1R #signaling ameliorates #intestinal #fibrosis via #metabolic regulation of #histone #H3K9 #lactylation in #epithelial cells. sciencedirect.com/science/articl….

Video Abstract📺#P2Y14R activation facilitates #liver #regeneration via #CREB/#DNMT3b/#Dact-2/β-#Catenin signals in acute #liver #failure. From Dr. Hu @ChinaPharmaceuticalUniversity; sciencedirect.com/science/articl….

Video Abstract📺#Parabacteroides distasonis promotes #liver #regeneration by increasing β-hydroxybutyric acid (#BHB) production and BHB-driven #STAT3 signals. sciencedirect.com/science/articl….

Video Abstract📺A retrospective cohort study of the #efficacy and #safety of oral #azvudine #versusnirmatrelvir/#ritonavir in elderly hospitalized #COVID-19 patients aged over 60 years. sciencedirect.com/science/articl….

Video Abstract📺#SAE1 promotes #tumor cell malignancy via #SUMOylation and liquid–liquid phase separation facilitated nuclear export of #p27. sciencedirect.com/science/articl….

Video Abstract📺#VenusMutHub: A systematic evaluation of #protein #mutation effect #predictors on small-scale experimental data. sciencedirect.com/science/articl….

Review✍️Advancements in #CRISPR/#Cas systems for #disease treatment. From Dr. Gong @SichuanUniversity. sciencedirect.com/science/articl….