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Excited to share our new pre-print: Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity | ChemRxiv doi.org/10.33774/chemr…

The Power of Binding: Using Trivalent PROTACs to Enhance Protein Degradation promegaconnections.com/the-power-of-b… via Promega Corporation

Our amide-to-ester subsitution paper is finally out now in J Med Chem! Big thank you to co-first author Tori Klein, to Conner Craigon and to Alessio Ciulli and Scott Lokey for helping to put together this cool story! pubs.acs.org/doi/10.1021/ac… #TPD #medchem #PROTACs

Innovator of the Year 🌟 Winner of best early-stage business idea: Adam Bond & Connor Craigon (CeTPD) for a BromoTAG is a new ligand-inducible degron system. Read about this work: buff.ly/3pl7MI2

Available Now! EXCLUSIVE to Tocris, BromoTag® AGB1 is a potent, fast, and selective degrader for targeting Brd4BD2 L387A fusion proteins that can be used in cells and in vivo: bit.ly/3PtcoXh Developed by: @Alessiociulli, Adam Bond , Conner Craigon & @Dundeeuni.

Excited to debut XL01126 – a first-in-class PROTAC degrader for the protein kinase LRRK2, a high-profile target in Parkinson’s disease. Great #CeTPD collaboration with Dario Alessi MRC PPU team and Rui Moreira Please share, thread below doi.org/10.26434/chemr…

I fucking love him so much. Today was a pick me up I needed, hopefully the players and staff too! 🔴💪🏻

🗣 "First of all they tried to blame Liverpool supporters, and now they're trying to blame fake tickets." Kaveh Solhekol questions the French Minister's response to the chaos at the Champions League final.

Here, in addition to describing a novel modality within the TPD field, namely an intramolecular glue degrader, we also shed light in an intrinsic BRD4-DCAF16 interaction. Perhaps this answers why BRD4 is such an easy target for PROTACs + glues! Thread below from. Great work all!

Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1alpha (HIF-1alpha) Stabilizers ift.tt/KBbP7fa #chemrxiv_biochem

I'm fundraising for The Institute of Cancer Research (ICR). Check out my JustGiving page and please donate if you can. Thank you! #JustGiving justgiving.com/fundraising/ad…

Very happy our work on improving VHL ligands is now out ACS Publications Bio & Med Chem Content #jmedchem great teamwork with Michael Gutschow and co. at Bonn. We design a new di-Methyl analogue of VH101 (cmpnd 30) and qualify it as the most potent VHL inhibitor in vitro and in cell pubs.acs.org/doi/10.1021/ac…

Excited to share our latest work combining VHL and CRBN in a single trivalent PROTAC to boost protein degradation. Great #TPD collaboration with @georg_e_winter and Kristin Riching, led by Adam Bond Miquel & Celia in each lab Centre for Targeted Protein Degradation CeMM Promega Corporation doi.org/10.26434/chemr…

This study was conducted in collaboration with Alessio's group Alessio Ciulli and was co-authored with my colleague Moutushi Islam (モウトシ). I would like to express my gratitude to everyone involved in this study. embopress.org/doi/full/10.10…

Happy to share that this work is now published in the Journal of the American Chemical Society J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Leveraging DualLigase Recruitment to Enhance Protein Degradation via Heterotrivalent Proteolysis Targeting Chimera Journal of the American Chemical Society Austrian Academy of Sciences University of Dundee Alessio Ciulli Centre for Targeted Protein Degradation #DualLigase #Protein #Degradation #Heterotrivalent #PROTAC pubs.acs.org/doi/10.1021/ja…

I am delighted to share the story that we've been crafting at the Centre for Targeted Protein Degradation in collaboration with Tocris Bioscience Bio-Techne for the last to years! We're thrilled to present BromoCatch - a self-labeling tag platform for protein analysis and manipulation. biorxiv.org/content/10.110…