🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

So happy to see the final version of our paper on the structure of the sensor-activated NRC2 hexamer online! Congrats to Jogi Madhuprakash and the whole team 👏 Check out Madhu's and AmirAli Toghani's threads below for the key highlights 👇🧵 science.org/doi/10.1126/sc…

Please retweet!🚨 We're hiring! 🚨 My lab IPMB Academia Sinica (中研院植微所) is looking for postdocs and research assistants to join us in studying NLR resistosomes in plant immunity, with opportunities in both fundamental and translational research. 🌱🔬 Learn more: sites.google.com/view/chwlab/ho… or DM me!

Happy to see this accepted and out on First Look at MPMI Journal You can read the final unformatted version here👇 doi.org/10.1094/MPMI-0…

Plant pattern recognition receptors: from evolutionary insight to engineering nature.com/articles/s4157…

I'm thrilled to announce that in 2025, I'll be joining the Spanish National Cancer Research Centre (CNIO) in Madrid to launch the Castells-Graells Lab! 🚀Check out our brand-new lab website: rcglab.com CNIO Stop Cancer

Great news: -Roger Castells-Graells is one of the most talented researchers I know. -A Spanish institute facilitates the return of a top researcher from UCLA. -My collaborator/good friend will now be closer. -There are two positions open with competitive salaries! Apply below👇

AlphaBind, a Domain-Specific Model to Predict and Optimize Antibody-Antigen Binding Affinity - Encode antibody and antigen with ESM2-nv (ESM2 but on NVIDIA), concatenate embeddings and feed into a lightweight transformer (4 attention heads, 7 layers) to predict binding affinity -

Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.110…

We’re delighted to share our latest preprint from the Hogenhout lab (Saskia Hogenhout, John Innes Centre) on the molecular mechanisms of plant-aphid interactions. We show how the aphid Mp10 effector protein acts as a local anesthetic, suppressing plant perception of aphid attack.

So glad to share that it's just published online. 'Conserved effector families render Phytophthora species vulnerable to recognition by NLR receptors in nonhost plants'. nature.com/articles/s4146…

5 days left to apply for the postdoc and research scientist positions in cryo-EM & protein design in our lab! 🔬🦠🧬 They're fully funded for 4 years. Salary: 42,800 euros gross per year. See details below:

We're happy to present a pre-print from the Hogenhout lab (Saskia Hogenhout), describing how a family of proteases in aphid oral secretions suppress plant immunity

RhoFold+ is an end-to-end language model-based deep learning approach for predicting 3D structures of RNAs. nature.com/articles/s4159…

A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀 Christopher Frank Dominik Schiwietz Lara Fuss @hendrik_dietz biorxiv.org/content/10.110…

Incredibly excited to share new results from Nabla Bio where we show we can design antibodies de novo for use in therapeutic discovery. We introduce JAM, an AI system we’ve developed to design de novo antibodies with good affinities, early stage developability, and function.