Riding on the wave of the recent CPIC guidelines on SLCO1B1 and statins, we show that the inclusion of gain-of-function variants in a haplotype-based model allows for better identification of patients at risk of statin intolerance. #preprint #PrecisionMedicine #AcademicTwitter

Robert Sladek comments on: Predicting the response to #GLP-1 receptor agonists: an unexpected role for β-arrestin-1 thelancet.com/journals/landi… #pharmacogenomics #T2D #diabetes #FREE to read with registration (also FREE)

Individuals with variants in GLP1R and rare low frequency variants in ARRB1 might benefit from earlier initiation of GLP-1 receptor agonists, linking ß-Arrestin1 mechanistically to the extent of glucose but not #weight reduction by GLP-1 receptor agonists #T2D Ewan Pearson

dundee.ac.uk/stories/dundee…

chatgpt #Rstats pkg creates unit tests, comments/explains/optimizes code, finds problems in code, refactors code, and perhaps the hardest of all, suggests good variable names for the result of code github.com/jcrodriguez198…

#OpenAccess Weight variability and cardiovascular outcomes: a systematic review and meta-analysis doi.org/10.1186/s12933… UoD Medicine Robert Massey, Moneeza K Siddiqui Ewan Pearson Dr Adem Dawed #Weight #Variability #Obesity #CardiovascularDisease #Type2Diabetes

🧬We're sticking with genetics this morning, hearing from Dr Adem Dawed, Prof Jordi Merino & Dr Amna Khamis on the latest from studies on genes & #Type2Diabetes. We're hearing how differences in our genes influence diabetes risk, diets & how people respond to drugs. 💊 #DUKPC

After almost 5 years of work (including a pandemic), our paper is finally out today in Science Advances. science.org/doi/10.1126/sc… Metabolism, Digestion & Reproduction

Excited to get this preprint out there showcasing an collaboration pooling data + expertise across 🇮🇳🏴󠁧󠁢󠁳󠁣󠁴󠁿🏴󠁧󠁢󠁥󠁮󠁧󠁿@Theodysse Andrew Brown Dr.V.Mohan Sarah Finer Rohini Mathur UoD Medicine Adem yesuf Sundararajan Srinivasan Colin Palmer The Scottish Health Research Register & Biobank medrxiv.org/content/10.110…

We offer an individual-level interpretation of polygenic score (PGS) transferability across genetic ancestries: PGS accuracy varies individual-to-individual across the genetic-ancestry continuum, even in populations usually labeled as homogeneous. 1/ nature.com/articles/s4158…

Excited to see our work on the genetic architecture of post-challenge insulin resistance out today in Nature Genetics: nature.com/articles/s4158… 1/6

Very much needed globally representative eQTL resource of 731 LCLs spanning all 26 1000G populations. Summary data and code: github.com/mccoy-lab/MAGE biorxiv.org/content/10.110…

When I thought I was done with the GWAS stories of 2023 and I should wrap up, stephen o'rahilly (its pronounced O-RA-hill-EEE) dropped yet another great paper from his team. How can I resist? It's storytelling time. In this hot-off-the-press Nature paper, Marlena Fejzo et al. uncover an absolutely fascinating

One of the clinical applications of PRS that I am curious about is identifying patients at risk of developing adverse effects when taking certain medications. Another example👇 x.com/doctorveera/st…

A new exciting study in Nature Metabolism by Luo et al. reports that those who lack lactase enzyme as adults (LCT-rs4988235 GG) but consume milk are at lower risk of type 2 diabetes (T2D) and this association is mediated via gut microbiome. Luo et al. Nat Met

#Phaeochromocytomas and #paragangliomas (PPGLs) release #catecholamines leading to catecholamine-induced #hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm Hg thelancet.com/journals/landi… #PPGLs

@GenesHealth, Sam Hodgson, Sarah Finer & I are very pleased to share the 1st study using partitioned polygenic scores to understand age of T2D onset, GDM, lean T2D & 💊 response. All this in a south Asian cohort – typically under-represented in 🧬 research Wolfson Institute of Population Health Clinical Effectiveness Group