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Happy to share our new lab preprint: biorxiv.org/content/10.110… Clump sequencing exposes the spatial expression programs of intestinal secretory cells. We developed a method for reconstructing spatial expression maps of rare tissue cells.1/5

Very excited to share our new paper on acinar zonation in diabetic mice. cell.com/cell-reports/f…

התחלואה לנפש לאורך המגפה: מה לומדים? גם ללא טיפול דיפרנציאלי, התחלואה התנהגה באופן שונה בכל מגזר. זה אומר שהערבוב בין המגזרים לא גבוה, לפחות לפרקי זמן מסויימים, ושניתן לטפל דיפרנציאלית במגזר החרדי היו שלושה גלי תחלואה המגזר הערבי בעיצומו של הגל השני שלו והחל לזלוג למגזר הכללי

Our new snapshot on liver zonation🎉🎉🎉 Check it out!!!!

Happy to share our preprint on the spatial expression programs of the intestinal follicle-associated epithelium biorxiv.org/content/10.110…. The small intestine is lined with rare small isolated lymphoid follicles aimed at sampling microbial antigens.1/5

So excited to share our new work lead by Adi Egozi and shalev itzkovitz identifying endogenous insulin producing cells in the fetal intestine. Yale Pediatrics Yale University Yale School of Medicine Insulin is expressed by enteroendocrine cells during human fetal development biorxiv.org/content/10.110…

Very excited with our new preprint, it was such a fun project to work on. A collaboration of shalev itzkovitz lab and Konnikova lab lab.

Excited to share our new preprint on liver zonal regeneration:biorxiv.org/content/10.110…. Acetaminophen overdose leads to massive necrosis of pericentral hepatocytes. Yet, within four days the liver fully regenerates (1/7).

Our paper is out Nature Medicine. Really fantastic collaboration with shalev itzkovitz led by brilliant Adi Egozi Insulin producing cells exist in utero in the fetal small intestine. So many possibilities. Yale Pediatrics Yale University Yale Medicine

Our paper is finally out today Nature Medicine!

Cell types outside the pancreas make insulin, too, study shows news.yale.edu/2021/12/09/cel… Thanks so much for highlighting our work with Adi Egozi shalev itzkovitz Yale Pediatrics Yale University Yale School of Medicine

Single-cell transcriptomic analyses of human fetal and neonatal intestinal cells reveal a sub-population of enteroendocrine cells that produce #insulin during development shalev itzkovitz Konnikova lab Adi Egozi Yale School of Medicine Weizmann Institute nature.com/articles/s4159…

Weizmann Institute of Science and Yale School of Medicine have discovered cells that produce #insulin in an unexpected place: the fetal intestine! These findings may open up new directions for the development of potential treatments for #diabetes bit.ly/gut-tw

Single-cell transcriptomic analyses of human fetal and neonatal intestinal cells reveal a subpopulation of enteroendocrine cells that produce insulin during development, according to a Nature Medicine paper. go.nature.com/3saUMGB

Proteins and mRNAs do not always correlate - Check out our new paper in Nature Metabolism to see how this happens in the gut: Spatial discordances between mRNAs and proteins in the intestinal epithelium. nature.com/articles/s4225…. 1/8

Excited to share our preprint on pan-cancer analysis of intra-tumor heterogeneity (ITH), led by Avishai Gavish and Mike Tyler. After exploring ITH in small patient cohorts, we now curated scRNA-seq data from >1,000 tumors to broadly define ITH patterns. biorxiv.org/content/10.110…

Our gut sheds around 35 grams of cells daily, making up a large portion of our feces. Our paper in Gut Journal shows that the host transcriptome of fecal washes is highly indicative of inflammation in IBD patients: gut.bmj.com/content/early/…. 1/5

Exited to share our new preprint! Another great collaboration with Konnikova lab lab.

Check out our new preprint on the after-life of intestinal cells: biorxiv.org/content/10.110…. Cells that are shed each day from our gut are thought to die immediately upon their dissociation from the tissue. Here we show that this is not the case (1/6).

An amazing collaboration with shalev itzkovitz led by Adi Egozi and Bunmi Olaloye M.D. One step closer to world without NEC. #NEC Yale Pediatrics Yale School of Medicine Weizmann Institute. #PLOSBiology: Single-cell atlas of the human neonatal small intestine affected by NEC dx.plos.org/10.1371/journa…