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A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling nature.com/articles/s4155…

SNP rs6543176 is associated with extreme human longevity but increased risk for cancer link.springer.com/article/10.100…

An mTOR Inhibitor Discovery System Using Drug-Sensitized Yeast biorxiv.org/content/10.110…

EBP1 potentiates amyloid β pathology by regulating γ-secretase nature.com/articles/s4358…

To start off 2025, we are very pleased to introduce a Special Issue on the Neuroscience of Aging, curated by Axel Guskjolen . We hope you enjoy every single piece of it as much as we do! cell.com/neuron/current

Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegeneration nature.com/articles/s4358…

I don't know if you realize how big of a deal this is...

Dying Occurs as a Progression of Discrete Molecular Events in Drosophila, Not Merely Nonspecific Physiological Collapse #preprint papers.ssrn.com/sol3/papers.cf…

Online now! Yang et al., show an age-related increase in the microbial-derived metabolite phenylacetylglutamine that drives host cellular senescence by inducing DNA damage and mitochondrial dysfunction via the adrenoreceptor-AMPK signalling. doi.org/10.1038/s43587…

Online now!✨RESEARCH: @ZaneKoch6 et al show that epigenetic clocks mirror the accumulation of somatic mutations, and explore how mutations at CpG sites coincide with remodeling of the surrounding methylome nature.com/articles/s4358… rdcu.be/d59Ib

Somatic mutation as an explanation for epigenetic aging nature.com/articles/s4358…

Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence nature.com/articles/s4358…

In the second case of a genetically modified pig heart transplanted into a living person, the heart functioned well initially, but antibody-mediated rejection occurred, highlighting the need for better strategies to avoid this issue. nature.com/articles/s4159…

Nearly three-quarters of biomedical researchers think there is a reproducibility crisis in science go.nature.com/42jwM60

"The science of extreme longevity continues as an immense joke." —The first man to “survive” past 110 actually died at 65. —Blue zones are a myth —Pervasive false claims about longevity and supercentenarians Gift link nytimes.com/2025/01/20/opi…

Reconciling 2 major explanations for #aging, study in Nature Aging finds somatic mutations are fundamental driver of aging and #epigenetic changes simply track process. Reversing aging may be harder than previously thought. Time to rethink strategies? nature.com/articles/s4358…

X chromosome passed from mother to daughter influences brain ageing nature.com/articles/d4158…

🗞️Our January issue is out!🎉 To start off 2025, we have pieces on immune surveillance in senescent cells, geriatric care, brain aging biomarkers, societal aging and intrinsic capacity, geroprotective or senolytic agents, and much more. Read it all here 👇nature.com/nataging/volum…

SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation nature.com/articles/s4146…