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🚨 Our paper is out today in Nature! 🎉🎉🎉 So excited - our paper on the neuronal influence in pancreatic cancer is out in NATURE. You can read here 👇👇👇 (nature.com/articles/s4158…)

Day 2 of #MyeloidMalignancies25 is underway. We have more exciting talks after lunch & the poster session later this evening 🗣️🍷 Chaired by: Iannis Aifantis Ross Levine

Leukemia scientists taking a couple of hours to try Greek wine at Manousakis winery during @Fusio_Conf #myeloidmalignancies25 !!

Congratulations to our poster winners and a huge thank you to Pershing Square Philanthropies for sponsoring the prizes #MyeloidMalignancies25

Closing the #myeloidmalignancies25 Fusion Conferences strong with Sanam Loghavi, MD صنم لغوی 🔬🧬 and a fantastic keynote by the one and only IdoAmitLab !!!

Excited to share with all our latest work on the use of single cell tools in following IDH mutant AML patients during their treatment! Out today Cell Stem Cell !! An amazing collaboration with AK Eisfeld & Elli Papaemmanuil, PhD & Dan Landau !!! Driven by the impressive Maria Sirenko

And here is the link to the paper: cell.com/cell-stem-cell… huge thanks to a number of collaborators including Sanam Loghavi, MD صنم لغوی 🔬🧬 , Eirini Papapetrou, MD, PhD Ross Levine Kelly Bolton and Eytan Stein! We could not do it without them.

Here are a couple of conclusions from this work: a) We have defined phenotypic consequences of acquired mutations in IDH1/2AML in primary patient samples on therapy (monotherapy, + (7+3)) b) IDH1/2AML upregulates inflammation and downregulates cell proliferation and DNA damage

This work was supported by a number of funders, including NYU Grossman School of Medicine and National Cancer Institute !!! I cannot stress more the role of the NCI in such studies that try to understand the molecular basis of cancer and profile patients during their treatment.

Delighted to share our study out in Cell Stem Cell today from the dream team Elli Papaemmanuil, PhD Iannis Aifantis AK Eisfeld Dan Landau! We profiled IDH-mutated AML patients to define how IDH and co-mutations shape the disease at baseline and responses to IDH-inhibitors. 🧵👇

IDH mutant AML— one of the most common molecular subtypes, with availability of targeted inhibitors—yet, a daily challenge to understand treatment response/resistance in our patients. Why? Meticulous work of Maria Sirenko Iannis Aifantis Elli Papaemmanuil, PhD Dan Landau

Seemingly “easy”, but very difficult to treat AML. Amazing team work is shedding new light by breaking down hierarchies and clonal structures Maria Sirenko Iannis Aifantis Ohio State Hematology Sanam Loghavi, MD صنم لغوی 🔬🧬 Elli Papaemmanuil, PhD Dan Landau

So grateful to Soobeom Lee Maria Sirenko 조진흐ㅣ Sun and the Iannis Aifantis Elli Papaemmanuil, PhD and Dan Landau s and Sanam Loghavi, MD صنم لغوی 🔬🧬 to work on this together.

Maria Sirenko Cell Stem Cell Elli Papaemmanuil, PhD Iannis Aifantis AK Eisfeld Dan Landau proud of u & this beautiful work of art, Maria!!! Congratulations to U & the team!! Soobeom Lee zhengxi Elli Papaemmanuil, PhD Dan Landau Iannis Aifantis AK Eisfeld Looking fwd to more groundbreaking work from U!! You untangled a lot of complex data w/ stunning figures & visuals.

Such a fantastic lineup! Can’t wait!

I am back with bakery reports, which I have neglected. Celebrating our recipient of a successful gene therapy for sickle cell. I was a little ambivalent about eating my head in the cake, but such is life!! The James The Ohio State University Wexner Medical Center he will be returning home to the UAE soon!!

The first issue of Blood Global Hematology is out with great hematology research from all other the world. Blood Journals Portfolio ASH Georgia Cancer Center

Our ⁦MD Anderson Cancer Center⁩ experience Technical and Clinical Validity of Assessing Measurable Residual Disease by Multicolor Flow Cytometry in an Unselected Acute Myeloid Leukemia Patient Cohort - ⁦Arch Pathol Lab Med⁩ #MRD #leusm #hemepath #AML pubmed.ncbi.nlm.nih.gov/40522873/

Science wins!!!! 💟☮️ #IYKYK

Amy is looking forward to reuniting with familar faces, and welcoming new ones to the upcoming Single-Cell Technologies conference next year! A reminder that this meeting has sold out BOTH times, so do not delay getting registered and joining Iannis Aifantis Rahul Satija and