Alan H Bryce (@alanbryce9) 's Twitter Profile
Alan H Bryce

@alanbryce9

Medical oncologist and cancer researcher specializing in Prostate Cancer. Chief Clinical Officer, City of Hope Arizona, Professor of Molecular Medicine,Tgen

ID: 1151449043622608896

linkhttps://www.cityofhope.org/alan-bryce calendar_today17-07-2019 11:10:19

703 Tweet

1,1K Followers

623 Following

Dra. María Natalia Gandur Quiroga (@nataliagandur) 's Twitter Profile Photo

💫🌟🔬 Unraveling the Genetic Landscape of Testicular Germ Cell Tumors (TGCT)! 🧬🌟💫 ❗️Largest whole-exome meta-analysis in TGCT to date sheds light on genetic predisposition in 1,435 cases vs. 18,284 controls. #ZeidKuzbari Charlie Rowlands #IsaacWade #AliceGarrett Chey Loveday

💫🌟🔬 Unraveling the Genetic Landscape of Testicular Germ Cell Tumors (TGCT)! 🧬🌟💫
❗️Largest whole-exome meta-analysis in TGCT to date sheds light on genetic predisposition in 1,435 cases vs. 18,284 controls. 
#ZeidKuzbari <a href="/CRowlandsBio/">Charlie Rowlands</a> #IsaacWade #AliceGarrett
<a href="/LovedayChey/">Chey Loveday</a>
GU Oncology Now (@guoncologynow) 's Twitter Profile Photo

📺 In part 1 of a new roundtable moderated by Alan H Bryce, expert panelists discuss advances in biomarker testing, treatment intensification, and best practices for integrating next-generation sequencing into clinical #prostatecancer care: buff.ly/6TYvvuL 👉 The panel

Jake Orme MD PhD (@jakeormemdphd) 's Twitter Profile Photo

So grateful to the brave patients and their families that made this clinical trial possible, an entirely new way to restore sensitivity to immunotherapy using plasma exchange. Mayo Clinic Mayo Clinic Comprehensive Cancer Center Fabrice Lucien, PhD Nat Comm rdcu.be/edrKN

Irbaz Riaz MD,MS,MBI,PhD (@irbazriaz) 's Twitter Profile Photo

Thrilled to celebrate my incredible fellows matching into Internal Medicine Residency programs! 🎉 Your hard work, dedication, and resilience have been truly inspiring. It’s bittersweet seeing you move to the next chapter—you’ve become family. Super proud and excited to see all

Thrilled to celebrate my incredible fellows matching into Internal Medicine Residency programs! 🎉 Your hard work, dedication, and resilience have been truly inspiring. It’s bittersweet seeing you move to the next chapter—you’ve become family. Super proud and excited to see all
Oncology Brothers (@oncbrothers) 's Twitter Profile Photo

A few things to keep in mind 1. 👇recent updates in prostate cancer staging 2. Solitary rib Mets on PET-PSMA are often benign 3. Response of PARPi based off HRR mutation (slide by Alan H Bryce) 4. Survival by subgroups (slide from Alan H Bryce) x.com/nicholaszaorsk…

A few things to keep in mind 

1. 👇recent updates in prostate cancer staging

2. Solitary rib Mets on PET-PSMA are often benign 

3. Response of PARPi based off HRR mutation (slide by <a href="/AlanBryce9/">Alan H Bryce</a>) 

4. Survival by subgroups (slide from <a href="/AlanBryce9/">Alan H Bryce</a>) 

x.com/nicholaszaorsk…
Alan H Bryce (@alanbryce9) 's Twitter Profile Photo

I have to challenge this. We don’t yet have clear trial data to establish platinum efficacy in HRR mutated mCRPC. However platinum is unequivocally more toxic than PARPi, especially with regards to neuropathy. I have had multiple patients on PARPi for >24 months. No way you

Sumanta K. Pal, MD, FASCO (@montypal) 's Twitter Profile Photo

Best talk I have been to all year was right here at City of Hope at our GU retreat (organized by Alex Chehrazi-Raffle, MD). Yun Rose Li City of Hope - Department of Radiation Oncology just delivered a tour de force highlighting her work in #prostatecancer w Tanya Dorff et al focused on fasting interventions & other metabolic

Best talk I have been to all year was right here at <a href="/cityofhope/">City of Hope</a> at our GU retreat (organized by <a href="/arafflemd/">Alex Chehrazi-Raffle, MD</a>). <a href="/yunroseli/">Yun Rose Li</a> <a href="/COH_RadOnc/">City of Hope - Department of Radiation Oncology</a> just delivered a tour de force highlighting her work in #prostatecancer w <a href="/TDorffOnc/">Tanya Dorff</a> et al focused on fasting interventions &amp; other metabolic
UroToday.com (@urotoday) 's Twitter Profile Photo

#TRITON3 final overall survival results for rucaparib in BRCA-mutated #ProstateCancer. Alan H Bryce City of Hope joins Alicia Morgans, MD, MPH Dana-Farber to discuss the phase III study which evaluated rucaparib against physician's choice therapy (predominantly docetaxel) in

#TRITON3 final overall survival results for rucaparib in BRCA-mutated #ProstateCancer. <a href="/AlanBryce9/">Alan H Bryce</a> <a href="/cityofhope/">City of Hope</a> joins <a href="/CaPsurvivorship/">Alicia Morgans, MD, MPH</a> <a href="/DanaFarber/">Dana-Farber</a> to discuss the phase III study which evaluated rucaparib against physician's choice therapy (predominantly docetaxel) in
Emmanuel Antonarakis (@eantonarakis) 's Twitter Profile Photo

Congratulations to Cathy Marshall on her two papers (in the same week!) exploring CH in solid tumors. This is an important and emerging field. Cathy Handy Marshall, MD MPH Tempus academic.oup.com/oncolo/article… mdpi-res.com/d_attachment/c…

Congratulations to Cathy Marshall on her two papers (in the same week!) exploring CH in solid tumors. This is an important and emerging field. <a href="/CathyHandy/">Cathy Handy Marshall, MD MPH</a> <a href="/TempusAI/">Tempus</a>  academic.oup.com/oncolo/article… mdpi-res.com/d_attachment/c…
Julian Chavarriaga (@chavarriagaj) 's Twitter Profile Photo

#AUA25 Ana Moser Wayne State University School of Medicine tackled the question: Who still needs a lymph node dissection with a negative PSMA-PET? Key findings included: 🔹 n=359 PSMA-PET before RP+PLND 📉 21 cN1: 15 pN0, 6 pN1; 28 cN0 were pN1 🎯 NPV: 91%, PPV: 29% ⚠️ cN0/pN1: More NCCN high-risk (65%) +

#AUA25  Ana Moser <a href="/waynemedicine/">Wayne State University School of Medicine</a> tackled the question: Who still needs a lymph node dissection with a negative PSMA-PET? Key findings included:
🔹 n=359 PSMA-PET before RP+PLND
📉 21 cN1: 15 pN0, 6 pN1; 28 cN0 were pN1
🎯 NPV: 91%, PPV: 29%
⚠️ cN0/pN1: More NCCN high-risk (65%) +
Rohan Garje, MD (@rohangarjemd) 's Twitter Profile Photo

🚨 New ASCO Guideline on #mCRPC just published! Glad to co-author recs on sequencing, #PARP inhibitors, #genomics, chemo & radiopharmaceuticals Grateful to expert panel R. Bryan Rumble Irbaz Riaz MD,MS,MBI,PhD #RahulParikh Alan H Bryce Journal of Clinical Oncology OncoAlert OncLive.com 🔗ascopubs.org/doi/10.1200/JC…

🚨 New <a href="/ASCO/">ASCO</a> Guideline on #mCRPC just published!
Glad to co-author  recs on sequencing, #PARP inhibitors, #genomics, chemo &amp; radiopharmaceuticals
Grateful to expert panel
<a href="/BryanRumble/">R. Bryan Rumble</a> <a href="/IrbazRiaz/">Irbaz Riaz MD,MS,MBI,PhD</a> #RahulParikh <a href="/AlanBryce9/">Alan H Bryce</a> <a href="/JCO_ASCO/">Journal of Clinical Oncology</a> <a href="/OncoAlert/">OncoAlert</a> <a href="/OncLive/">OncLive.com</a>   
🔗ascopubs.org/doi/10.1200/JC…
Alan H Bryce (@alanbryce9) 's Twitter Profile Photo

Great data. I’m particularly impressed by the benefit seen in with Talazoparib + Enzalutamide CDK12 mutant mCRPC. PFS and OS benefit. I think this is still an underappreciated benefit.

Alan H Bryce (@alanbryce9) 's Twitter Profile Photo

IMO the most important message here is the importance of paying attention to CV dz for men with advanced PC. Our must do checklist for men with advanced PC should include: 1) Germline + somatic NGS 2) Manage CV health 3) Manage Bone health