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🧵Is brain fog biological or psychological or both? 🚨1/14 The number of people dismissing brain fog as “psychological” often overlook that neuroinflammation, glial dysregulation, BBB disruption, and altered interoceptive processing are biological processes deeply embedded in

This is an excellent article that explains these issues, and the ongoing assault on the FDA, and the perspectives of people like Reshma Ramachandran who have pushed to reform the FDA in their work but who are now fighting to save it from these depredations. nytimes.com/2025/07/08/mag…

As a collector I love first appearances of classic essays and stories. Found this gem just now on eBay!! Can you imagine? You go out to your mailbox. "Ah, wonderful, the latest issue of Horizon. What's this? An Orwell essay? I did enjoy his Animal Farm..."

For The Ick, I wrote about how millennials gave themselves misophonia for the word moist, how the emotional response to misophonia may actually be bi-modal, and the scientific reason I cannot tolerate the sound of bananas — link below

When I graduated from college, my wife and I moved to China and took jobs teaching English at a K-12 boarding school. (Yes, *K*) The boarding school was housed in an abandoned America Land theme park. Kids dorms were in a replica Mt Rushmore. Offices in replica White House.

The Rehearsal is the wildest, most brilliant work of art I’ve encountered in a long time. Watching it is transformative.

AI and plastic surgery related question: If light green eyes are strikingly attractive, why haven’t colored contacts become extremely popular?

Vaccine skepticism is primarily caused by broken trust, not lack of adequate information.

I was one of the 16 devs in this study. I wanted to speak on my opinions about the causes and mitigation strategies for dev slowdown. I'll say as a "why listen to you?" hook that I experienced a -38% AI-speedup on my assigned issues. I think transparency helps the community.

Learned a new word today!

Dwarkesh Patel The way people use LLMs are probably how people initially used automobiles. Dude, in 1860 - "I'm going to try driving my car from Chicago to California. Maybe it will just work. Would be nice if I don't need to use my horse."

If a man is in Virginia wearing a cowboy hat and Birks, is he more likely to be liberal or conservative?