Overcoming the Lack of CD2:CD58 Costimulation in Chimeric Antigen Receptor T-Cell Immunotherapies ashpublications.org/blood/article/… 1/504/530305/Overcoming-the-Lack-of-CD2-CD58-Costimulation-in #ASH2024

Grateful to #ASH2024 for the chance to present our work on overcoming the absence of CD2:CD58 co-stimulation using an innovative PD1:iCD2 switch receptor. Thanks to my mentor Marco Ruella and the Ruella Lab for their invaluable support. Excited to delve deeper into this approach!

New #JITC review: Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review bit.ly/40jqaCc @mcquadeMDLAc Marco Ruella Chris(tine) Spencer Allison Betof Warner, MD, PhD Tullia Bruno, PhD

📢 Excited to share our Society for Immunotherapy of Cancer review: "Advances in the understanding and therapeutic manipulation of cancer immune responsiveness"! Grateful to Francesco Marincola and Marco Ruella for the opportunity to contribute! pubmed.ncbi.nlm.nih.gov/39824527/

Online Now: EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models dlvr.it/TJ5ghB

Exciting news: EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models Cancer Cell Marco Ruella Alberto Carturan Puneeth Guruprasad Ruchi Patel Yunlin Zhang Guido Ghilardi and my stellar co-author Siena Nason cell.com/cancer-cell/ab…

CHOP & Penn Medicine have delivered the first-ever personalized gene editing therapy for a patient with CPS1 deficiency, marking a major milestone in the application of CRISPR-based treatments. Learn more about KJ & the future of personalized medicine: ms.spr.ly/6015SZLAx.

Human T cells are now relatively easy to modify ex vivo, but mouse T cells are a bit finicky. We made a resource in Nature Protocols for CRISPR-editing of primary mouse T cells, hoping to establish a pipeline for generating knockout CAR T cells for use in syngeneic models.

New Nature Protocols out!📢 An optimized workflow to generate gene-edited murine CAR T cells for immune-competent models, advancing studies of CAR T biology in native TME. Congrats Puneeth Guruprasad Marco Ruella Ranjani Ramasubramanian Alberto Carturan Shan Liu nature.com/articles/s4159…