FYI - this report can be found free - open access below: Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis rupress.org/jem/article/22…

Results from a recent phase 2 trial show tulisokibart, a new treatment for #UC, leads to clinically significant remission. The therapy targets TL1A and shows promise among patients with a higher genetic likelihood of response. Bruce E. Sands gastroendonews.com/Inflammatory-B…

Dr Anne Griffiths of The Hospital for Sick Children (SickKids) received the CAG Research Excellence Award at #cddwclm2025, introduced by Aleixo Muise - and in true fashion, acknowledges her mentees immediately!

Exome and genome sequence analysis, together with follow-up functional analyses, yielded a genetic diagnosis in 62 of 129 infants (48%) with congenital diarrhea and enteropathy. Full study results: nej.md/3E1p2Md #Gastroenterology

A new study by Aleixo Muise and physician researchers at The Hospital for Sick Children (SickKids), published in NEJM, identifies novel genes associated with rare childhood diarrhea. This discovery enhances our understanding of gastrointestinal disease in early life, particularly rare and severe forms of

Very excited to share our latest work -demonstrating 50% diagnostic rate for CODE and 3 new CODE genes, MYO1A, GRWD1, and MON1A. NEJM The Genetic Architecture of Congenital Diarrhea and Enteropathy | New England Journal of Medicine nejm.org/doi/abs/10.105…

wonderful meeting!!

Descubren genes clave en bebés con trastornos digestivos raros que provocan diarrea y malabsorción severa serpadres.es/salud/nuevos-g…

Novel genes linked to rare childhood diarrhea sickkids.ca/en/news/archiv…

New #SKResearch study in NEJM from Dr. Aleixo Muise has identified new genes linked to rare childhood diarrhea, increasing diagnosis rates and moving researchers closer to precision therapies for the conditions. Read ⤵️ sickkids.ca/en/news/archiv…

Original Article: The Genetic Architecture of Congenital Diarrhea and Enteropathy nej.md/3E1p2Md #Gastroenterology

Genomic sequencing identifies variants linked to congenital diarrhea and enteropathies dlvr.it/TK5mZT #ChronicDisease #Gastroenterology

📚 New research in NEJM by uncovers the complex genetic underpinnings of congenital diarrhea and enteropathies. In a study of 129 infants, researchers identified causal variants in nearly half of them, paving the way for targeted therapies. 👉 doi.org/10.1056/NEJMoa…

We are excited to invite you to the upcoming Pediatric IBD School 2025 session, Join us on Monday May 26th 2025, from 7:00 PM to 8:00 PM for this engaging virtual event. Everyone is welcome to attend! zoom.us/webinar/regist…

It’s World Digestive Health Day! While we work toward finding a cure for Crohn’s disease, we know early identification and treatment are vital to long term health outcomes. The Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES-21) consortium, including

A few lab updates: Our major consortium paper on the genetics of Congenital Diarrheas and Enteropathies came out last month. A major collab between BCH, SickKids (Aleixo Muise), UCLA (Martin Martin) and Vanderbilt (Goldenring Lab ) pmc.ncbi.nlm.nih.gov/articles/PMC11…

1/ Following 1st IBD GWAS 2005 at University of Oxford implicated TNFSF15 in CD - huge effort with colleagues at IBD at Cedars-Sinai & Prometheus Bio ➡️novel Rx in CD. Has been my passion to deliver benefits of genomic advances to improve lives of people with IBD 🌍 thelancet.com/journals/langa…

Dr Dermot McGovern University of Oxford IBD at Cedars-Sinai congrats Dr Dermot McGovern, outstanding effort going from GWAS to getting anti-TL1A monoclonal antibodies to patients!!

Dr. Aleixo Muise (Aleixo Muise) of University of Toronto and The Hospital for Sick Children (SickKids) is discussing what monogenic IBD teaches us about precision IBD treatment. #InnovationsSymposium2025