Great thread: Where #StrepA burden greatest frequent lineage replacement seen. Interesting points: "vaccines without broad cross-lineage protection may also lead to S. pyogenes lineage replacement." "need to do better surveillance from carriage and non-invasive disease"

#NewStudyAlert 🆕research led by scientists MRC Unit The Gambia at LSHTM London School of Hygiene & Tropical Medicine uncovered vital evidence that could fast-track the development of a vaccine against Streptococcus pyogenes (Strep A), a major cause of childhood illness & death worldwide. Read more 👉 tinyurl.com/44azs8dy

[1/2] "Streptococcus pyogenes leads to 500,000 deaths annually, many due to rheumatic heart disease in low-income settings. Limited understanding of natural protective immunity to S. pyogenes hinders vaccine development." Nature Medicine nature.com/articles/s4159…

#Identification of protective antibodies in children marks a major advance toward a #StrepA #Vaccine, offering potential to prevent hundreds of thousands of deaths worldwide each year. The University of Sheffield Nature Medicine doi.org/g9wjrh medicalxpress.com/news/2025-08-s…