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Our paper on indirect assortative mating is now out in Nature Communications! In it, we provide refined definitions of terms used to explain partner similarity, develop statistical models, and find evidence of surprisingly high social homogamy for education. Link: nature.com/articles/s4146…

Were the first kings of Poland actually from Scotland? New DNA evidence unsettles a nation’s founding myth theconversation.com/were-the-first…

Another argument for why the west is best for nature.

Not bad for a stage IV cancer patient

Amazing new paper from Qiaomei Fu et al. confirms that the Harbin skull is indeed a Denisovan! Incredibly exciting

Studying the genetics of intelligence measures can help us understand the neurobiology of cognition and neurodevelopmental conditions 🧬🧠 We estimated missing intelligence test scores in UK Biobank to reduce bias and boost power. Preprint: medrxiv.org/content/10.110… Thread 👇

Part 1 of my three-part monograph ‘Behavioral Genetics and Human Agency’ is now live at Twin Research and Human Genetics. The subtitle and abstract (pictured) should give you a quick sense of what it’s about. An Open Access link is provided at the end of this thread. 1/10

New preprint - collab with the groups of Matt Hurles and Abdel Abdellaoui. We imputed missing fluid intelligence test scores into ~170k UK Biobank individuals & showed how this increases power for rare+common variant analyses. medrxiv.org/content/10.110…

These results are inconsistent with similar previous analyses such as this from our education GWAS paper. For IQ, the PGS effect shrunk to 84% as large (S.E. 3.3%) within-family. We used a much larger sample than this study, meta-analysing across UK Biobank, Swedish Twin

Sasha Gusev It is odd that Plomin is on the board of Nucleus — apparently offering within-family IQ screening for embryos — yet publishes a paper saying IQ prediction doesn't work very well within-family...

I helped Scott Alexander with this post. At least with respect to some traits (e.g. education, bmi), we are in an epistemic crisis about their heritability. We have multiple strong methods - twin studies, RDR, sibling, GREML-WGS - that are not converging on a consensus reality.

Nice article. We need better estimates of important biological parameters and the estimates we have now -- if all taken at face value -- neither agree internally nor agree with any single coherent theory.

An article like this was definitely needed: easy to follow and outlines the conceptual territory well. Wanted to share some constructive feedback in this thread! cc: Scott Alexander

Nice summary of different estimates of the heritability of BMI. Could be anywhere from 30% to 75% depending on which method is used, and we don't have compelling reasons why they differ.

🧵1/7 New study: How do adolescent cognitive ability and education predict adult mental disorders? 🧠📚➜🧑‍⚕️ Using Norwegian register data (N = 272,351 men) with GP diagnoses and military assessed cognitive abilities. 👇

Why is logging into my work email 10x harder than logging into my bank?

It's funny how people think they can just assert the linear model doesn't work without any argument or evidence like no one has ever thought of this before or looked into it.

Alex Strudwick Young Lagoon "This is in keeping with my expectation that lots of small perturbations to a complex system (as effects of common variants generally are) can be well approximated by a linear map." is your most underrated take.

Short Sleep Variants Do Not Replicate In March Kristjan Moore from deCODE genetics emailed me urging me to stop working on short sleep. I read paper in question since Jan, but was still hoping/coping that maybe NPSR1 variant (not included in the paper) would replicate.

Our study led by R. Bhattacharya & Chris Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are: 1. Hypertension 2. CAD polygenic risk score ahajournals.org/doi/10.1161/CI…