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We release a Topaz GUI and several updates: github.com/tbepler/topaz Topaz is a novel deep learning particle picker that can pick any shape & size particle, e.g. all orientations of the particles in the logo. The GUI works on modern web browsers; test here: emgweb.nysbc.org/topaz.html

Congratulations to Gabe Lander Lab for winning the proteinsociety Young Investigator Award!

Protein denaturation at the air-water interface and how to prevent it dx.doi.org/10.7554/eLife.…

Well deserved, Congrats!

Cryo-FIB/SEM Opportunity for people in the NYC and surrounding areas: Contact me or Bridget Carragher if you would like to become a major user of a Zeiss Crossbeam cryo-FIB/SEM. Please send a description of your potential biological project(s).

We present Topaz Denoiser, a method for denoising cryoEM images based on Noise2Noise. A pre-trained model that takes only a few seconds to denoise an image on a GPU is included, or you can train your own model. Topaz v0.2.1 is available for free here: github.com/tbepler/topaz

Cool

#cryoEM #ProteinCrystallization #StructuralBiology ow.ly/TkHa50v0FVu

Going to #MM2019Portland & ready to learn about the NIH Common Fund Transformative High Resolution #cryoEM program? Meet us at: 1) Short Course X-10 B110-111 Sun Aug 4 8:30A 2) X30.1-Tech Forum B117 Wed Aug 7 10:30A 3) Booth 652 by PNCC with SLAC #S2C2 & NCCAT Info

Where’s Ed at #MM2019Portland contest: Find me, talk about NIH #cryoEM programs & get a timed prize*. Sa/Su: I <3 NY hat/T-shirt M: Chameleon plushie (exhibit hall only) T: I <3 NY hoodie W: NCCAT T-shirt Th: mini plushie (*no cost, 1 ea, unclaimed prizes forwarded to next day)

For the folks attending M&M 2019 in Portland the next days, please check out my fantastic colleague Felix Weis’ talk on Monday at 2PM, B110, on how we run our cryo-EM platform EMBL Please RT! #MM2019Portland

Our first PNCC Open House will be occurring on August 8th, 2019 at 5:30pm until 7pm in Robinson Life Science Building, Portland OR. We will be picking guests up from the "PNCC Meeting Point" every 15 mins. See you there!

We are seeking two researchers for 𝘪𝘯 𝘴𝘪𝘵𝘶 structural cell biology, including working hands-on with cryo-FIB/SEM, cryo-CLEM, cryo-ET, automation, and computational methods. Let us know if you are interested in 𝙝𝙖𝙫𝙞𝙣𝙜 𝙛𝙪𝙣 with us!

Topaz v0.2.3 is out! Thanks to all the testers and developers who helped get Topaz to where it is today. The update adds the general denoising models in the Topaz-Denoise preprint, a pre-trained picking model, & an updated GUI. cb.csail.mit.edu/cb/topaz/ emgweb.nysbc.org/topaz.html

Keep up the good work. 👍

Nice

It’s the 2nd day of May, but have 2 days, 2 weeks or 2 months passed? Wondering how to keep track of time? Let SEMC help you count days one micrograph at a time through #microscopy Download the full #SEM Calendar through our new #science outreach page: nccat.nysbc.org/activities/ncc…

Wow! Cold FEG + Falcon 4 + RELION = 1.22 Å of apoferritin. Great for #CFAR, but what's more impressive is the reconstruction of β3 GABAA receptor with regions resolved to ~1.6 Å! Congrats Sjors Scheres & colleagues! What a day for the #cryoEM community biorxiv.org/content/10.110…

Check out The Action Lab's video! #TikTok tiktok.com/t/ZT8Tu7gP2/

Join us on November 1 to celebrate the arrival of cryo-EM in Newark! Together with Alex Wei and @NeiditchLabRU, we are hosting the inaugural NJMS Cryo-EM Symposium Rutgers New Jersey Medical School Rutgers Health . Registration is available via the following link: njms.rutgers.edu/research/sympo…