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🆕 #NIDA-supported research in JAMA Pediatrics: Characteristics Associated With Cannabis Use Initiation by Late Childhood and Early Adolescence in the Adolescent Brain Cognitive Development (ABCD) Study. @WUSTL jamanetwork.com/journals/jamap…

New preprint! Prenatal cannabis is associated with worse adolescent mental health. Could this be because of an effect on brain development? medrxiv.org/content/10.110…

Adolescents and young adults with mild or moderate alcohol use disorder (AUD) endorsing specific high-risk AUD diagnostic criteria are at increased risk for progression to severe AUD independent of the number of prior diagnostic criteria endorsed. ja.ma/3QbLcyM

🧬🧠 Check out our latest preprint on the genetics of impulsivity! medrxiv.org/content/10.110… In this paper, we examined ‘lumping’ versus ‘splitting’ models of impulsivity and characterized the shared and unique biology across multiple levels. A few key findings below! 🧵

Happy to share two new(-ish) papers from my dissertation examining support for dual-systems models of the genetic architecture of impulsive traits (bit.ly/3wzTLfe) and neurogenetic overlap between sensation seeking, alcohol consumption, and AUD (bit.ly/43l0Ahj).

New preprint led by Alex P. Miller, in which we identify several structural MRI correlates of substance use initiation the ABCD study, with evidence that these largely reflect preexisting risk! medrxiv.org/content/10.110…

Excited to share new work (~half of my dissertation!) just out in 𝗣𝘀𝘆𝗰𝗵𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗠𝗲𝗱𝗶𝗰𝗶𝗻𝗲! doi.org/10.1017/S00332… Big thanks to my wonderful co-authors, David Baranger, @e_covey_johnson, @jackson_josh_, Aaron Gorelik, Alex P. Miller, AlexanderSHatoum, ...

Our article exploring the neurobiological correlates of prenatal cannabis exposure is now out! "Prenatal cannabis exposure, the brain, and psychopathology during early adolescence" rdcu.be/dMJqH

In a new nature study, a team of researchers at YSM, @JacksonLab, and Broad Institute use generative #AI to create #DNA sequences never seen in nature. The synthetic sequences can selectively turn #genes “on” and “off” in targeted cell types: brnw.ch/21wO2Go

🆕 from #NIDA: Brain structure differences are associated with early use of substances among adolescents. @WUSTL #ABCDStudy go.nih.gov/7O3Vuta (1/3)

Pre-existing brain structure variability in children, eg, greater whole brain, cortical, and subcortical volumes, and thinner prefrontal cortex, but thicker cortex elsewhere, was linked with earlier substance use. Alex P. Miller ja.ma/3DKAuex

A polygenic score calculated using concordant single-nucleotide variants may potentially be used to evaluate people with alcohol use disorder risk. ja.ma/3Dwx0wq