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Ever wonder about the mechanics of immune cell #migration? Caillier Alexia, Patrick Oakes Loyola University Chicago and colleagues find T cells form integrin mediated focal adhesions to pull themselves through confined spaces. hubs.la/Q02Cjd1r0 #Immunology #Adhesion

Really proud to see this paper finally out ! 🤩🎉🍾 Thank you to Journal of Cell Biology and the reviewers for their precious comments that definitely strengthened our work. See our previous thread for most of the details ! x.com/pwoakes/status…

How do cells squeeze their large nucleus through tight spaces? In work now published at J Cell Science, we show that cancer cells can use contraction of the rear cortex to generate pressure in the back and push the nucleus during confined #migration: journals.biologists.com/jcs/article-ab…

T cells use focal adhesions to pull themselves through confined environments, say Alexia Caillier (Caillier Alexia), Patrick Oakes (Patrick Oakes) Loyola University Chicago and colleagues: hubs.la/Q02DfTfd0 #Immunology #Migration #motility #Biophysics #Adhesion #integrins

Video shows Th1 Vinculin-EGFP cells sandwiched between two acrylamide gels of 460 Pa coated with FN. From Caillier Alexia, Patrick Oakes et al. showing that T cells use focal adhesions to pull themselves through confined environments hubs.la/Q02CjPHb0 #Immunology #Adhesion

What controls whether cells - or clusters of cells - break off from an invading cancerous front? New preprint from my group in collaboration with the Konstantopoulos group Konstantopoulos Lab , led by Wei Wang (汪巍) doi.org/10.1101/2024.0…

Looking for a summer read?🏖️🌞📄 You're in luck 😂. Our paper on optogenetic leader cells is out Nature Physics. We found a force-velocity relation for collective cell migration. Experiments by Leone Rossetti, theory by @ricardalert. IBEC rdcu.be/dQDmM

In their Review, @Stefano_R_Sala, Caillier Alexia and Patrick Oakes Loyola University Chicago discuss the principles and regulation of mechanosensing. journals.biologists.com/jcs/article/13…

We wrote a fun review all about the different types of mechanosensing and the ways cells regulate these important processes. Check it out!

Help choose JCB’s cover of the year! 🔬 Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. 🗓️ Voting closes on Friday, December 20! Have your say in celebrating the beauty of science 👉 hubs.la/Q02Z-YN70 #CellBio2024

I'm spending more time on the other social network these days, but it's still worth posting that we'll be at #cellbio24 #ASCB! If you like LIM proteins or septins come check out our posters:

It's a pleasure to share the first manuscript from my lab! biorxiv.org/content/10.110…

Excited that the peer-reviewed version of our fascin structure paper is now out in NatureStructMolBiol. Thanks very much to the referees for their constructive feedback. rdcu.be/d6Tct

.Journal of Cell Biology's new collection examines the mechanical properties and interactions that shape the fundamental operations and structures of cells. Delve into diverse mechanical properties of membranes, organelles and other structures within & among cells 👉 hubs.la/Q036nwR40

.Caillier Alexia, Patrick Oakes et al. find that T cells form #integrin mediated focal adhesions to pull themselves through confined spaces. hubs.la/Q036p18L0 In #Mechanobiology 2025: hubs.la/Q036nQwX0

Interested in nuclear #mechanobiology, and how advanced genomic tools can shed light on how the cell nucleus might sense mechanical forces? Read our latest review by excellent Julien Morival and Anna Hazelwood, now published J Cell Science: journals.biologists.com/jcs/article-ab…

📢 Mar 17: CPS Special Seminar! Join us for the in-person presentation by Dr. Patrick Oakes, hosted by Dr. Guy Tanentzapf: "Strain Signaling: “How LIM domain proteins coordinate mechanotransductionat adhesions”" 📷 Mar 17, 1pm in LSC 3 & Zoom

Our Immune Cell Biology collection emphasizes cellular dynamics, immune regulation, and disease mechanisms. Explore the mechanisms of dendritic cell regulation, T cell migration, neutrophil spreading and macrophage motility in tumor invasion: hubs.la/Q03jXHVl0 #AAI2025

Caillier, Patrick Oakes et al. find that T cells form #integrin mediated focal adhesions to pull themselves through confined spaces. hubs.la/Q03jXT9J0 📕 In Immune Cell Biology 2025: hubs.la/Q03jXWHM0 #AAI2025