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I'll be in Lausanne next Monday, will finally visit the Dubochet Center for imaging &co, Henning Henning Stahlberg. Very excited, come to see my talk if around

100,000's of our #cryoEM Autogrid Rings have been used since 2023 without issue. They're inspected w/multiple processes, including a visual inspection of every ring by experts.Our passion to make the best rings is evident in quality&package!See them #MM2024 MiTeGen TedPellaInc

Happy to announce our new preprint done in collaboration with Matteo Dal Peraro and Chan Cao labs

Come join us at EPFL! We are looking to fill a new position for a Tenure Track Professor in Chemical Biology! Find all info how to apply here: epfl.ch/about/working/…

It was a great pleasure to visit the amazing Dubochet Center for Imaging Dubochet Center for Imaging (DCI) at EPFL Lausanne 🇨🇭 and give a keynote talk for their inaugural symposium. What an impressive set of equipment and a panel of top-notch specialists!! Thank you alexmag for the invitation 🙏🙏

1/5 Happy to share our new preprint with co-first author Meghna Gupta biorxiv.org/content/10.110… Stroud Lab, MGupta Lab, James Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Eng, Tomo Kawate, Sree Ganesh Balasubramani, Andrej Sali lab, Deborah Hung, Robert M. Stroud Robert M. Stroud.

Thanks to everyone for the amazing response to BindCraft! 🔥🚀🖥️ Feel free to DM me or write on Github if encounter targets where the pipeline fails to generate binders, we want to use the feedback to improve it! P.S: here is a "helicopter" binder against DerF21 dimer

Initial results with nsTEM showed promising results also for the big proteins. So, we reached out to the fantastic Dubochet Center for Imaging (DCI) for cryoEM investigation and obtained high resolution structures for a 950 and 1000 AA protein,completly de novo designed! .

I‘m happy to share our work on laser flash melting to overcome preferred orientation in cryo-EM samples! 🥳❄️🔬 More infos on the underlying mechanism of particle redistribution and the use for preferred orientation issues in the 🧵 or here: biorxiv.org/content/10.110…

Structures of GluK2 kainate receptor in complex with spermine and polyamine-containing toxins elucidate the trapping mechanism of channel block and provide a template for designing new drugs. Shanti Pal Gangwar Maria Karela Laura Yen Maria Kurnikova nature.com/articles/s4146…

In our latest work we visualize continuous motion of nucleosomal DNA by human chromatin remodeler SNF2H. biorxiv.org/content/10.110…

Happy to share our last work. Wadjet-I SMC hinges are gates allowing selective bypass of obstacles connected through ssDNA BUT are dispensable for extrusion of naked DNA. Great teamwork with Honsworth, Taschi at Gruber lab with James & DNA Topology Lab biorxiv.org/content/10.110…

Scott C Blanchard and I are looking for a driven postdoctoral fellow to lead our joint efforts combining single-molecule biophysics with cryo-EM to understand important mechanisms of novel genome-editors. We have a very exciting joint project that addresses key questions in the

In collaboration with the Posthaus Lab, we identify ANTXR2—also the anthrax toxin receptor—as the receptor for Clostridium perfringens NetF pore forming toxin. Cryo-EM shows extensive contact between the pore and the receptor #Microbiology #CryoEM doi.org/10.1101/2025.0…