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💉 Dexmedetomidine sedation in adults on MV in #ICU, rapid practice guideline: use suggested over other agents, if desirable effects including ⬇️ #delirium valued vs undesirable, including ⬆️ hypotension & bradycardia - weak recommendation (suggestion). 📎 bit.ly/3lo4f8G

Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline. Free accessible at rdcu.be/cNXdv

💥Just Out ACTT-4 Trial👉First Double Placebo-Controlled Double-Blind Randomized-Stratified Head-to-Head #DEXAMETHASONE vs #BARICITINIB for hospitalized pts w/#COVID19 Low/High-Flow/NIV Relevant👉Patient Care/Public Health/Guidelines Our results 👇 bit.ly/3Gac9w7 🧵1/4

New publication with an aim to formulate evidence-based guidance for the use of dexmedetomidine for sedation in invasively mechanically ventilated adults in the ICU! doi.org/10.1007/s00134… #evidencebasedmedicine #clinicalresearch

Our comprehensive systematic review that summarizes the efficacy of dexmedetomidine vs other sedatives in intubated patients. 77 RCTs, 11,997 patients. Thought provoking outcomes and subgroup findings. Discusses the direction of future research! link.springer.com/article/10.100…

Dexmedetomidine vs other sedatives in adults on MV associated with ⬇️delirium (moderate certainty) ⬆️time at target ⬇️duration of MV & #ICU LoS (modest/low certainty) ⬆️bradycardia (moderate certainty) & hypotension (low certainty) #FOAMcc SR/MV of RCTs 🖇 rdcu.be/cOTkd

Authors should restrain themselves from telling readers what they believe or what they think is important. Rather, they should argue compellingly so that readers will themselves conclude what is important, or what is appropriate to believe.

It’s an honour to present the #COVIPRONE trial at #ERSCongress on behalf of the team! Our paper was selected as one of the best abstracts 💪 🦠 🧪 Waleed Alhazzani Ken Parhar @StelfoxTom Zainab Al Duhailib Yaseen Arabi SarahCulgin Department of Medicine UAlberta Medicine #ERS2022 ERS Assembly 2

Interpreting results of network meta-analysis in a way that is optimally useful to clinicians still a challenge. Innovative approach from the GRADE working group is very helpful–indeed, when 6 or more interventions under consideration, the best available. bmj.com/content/371/bm…

Just published SR antibiotics to prevent pneumonia in ICU. Shows problems Bayesian presentations. Mortality RR 0.91, 95% credible interval 0.82–0.99. Borderline significance should leave uncertainty. Authors say 99.3% probability of benefit. Wrong message doi.org/10.1001/jama.2…

The direct link for the job: linkedin.com/jobs/view/3349…

Exited to share our article published today, lead by Laiya, a rising star. Laiya taught our junior colleagues SR/MA methodology step-by-step, and produced this rigorous study. Proud of her & all the authors for their hard work. Lucky to get to be a part of Laiya's journey!

Our study found that awake prone positioning compared with usual care reduces the risk of endotracheal intubation in adults with hypoxemic respiratory failure due to COVID19. Great team work👌🏻 ⁦Jason Weatherald MD⁩ ⁦Ken Parhar⁩ ⁦Waleed Alhazzani⁩ bmj.com/content/379/bm…

Prevention of upper gastrointestinal bleeding in #ICU 🩸risk factors 🩸gastric protection 🩸clinical effectiveness of stress ulcer prophylaxis 🩸safety of SUP: mortality, nosocomial pneumonia, C. difficile infection, CV complications 🩸SUP evolving role 🖇️ bit.ly/3GgdmSV

For a general introduction to the GRADE approach, see this editorial doi.org/10.1016/j.bja.… from British Journal of Anaesthesia (w/ Waleed Alhazzani and Morten Hylander Møller) or the GRADE Handbook at gdt.gradepro.org/app/handbook/h…. 3/..

Awake proning in patients with COVID-19-related hypoxemic acute respiratory failure: A rapid practice guideline. Fortunate to work with a dedicated team on this RPG using GRADE. Waleed Alhazzani SharonEinavMD Prashant Nasa swagata tripathy Yaseen Arabi @Simon_Ocz

🚨 New The Saudi Critical Care Society Clinical Practice Guidelines on the prevention of VTE in adults with trauma have been published in ANNALS OF INTENSIVE CARE - AIC 📚 Access the full publication here: annalsofintensivecare.springeropen.com/counter/pdf/10…

STRATUS Trial published JAMA 🩸Cluster trial 25 ICUs >27,000 patients 🩸Switch to “small-volume” tubes that⬇️blood drawn for lab tests may⬇️RBC transfusion↔️effect on testing 🩸Available, cost-neutral, compatible with analyzers – will you switch? jamanetwork.com/journals/jama/…

Among patients with COVID-19 and acute hypoxemic respiratory failure, awake prone positioning is associated with improved clinical outcomes. ja.ma/3FogfET Oriol Roca, Waleed Alhazzani, @edqian, @toddrice_icu