Pleased to announce our latest work is now live at Nature Metabolism (@natmetabolism), in which we show polygenic risk scores (PRS) can be used to identify novel and causal proteins underlying disease risk. nature.com/articles/s4225… Thread 1/9

NEW from Min Seo Kim, MD, MSDH and Xiong Yang An Integrated Germline and Somatic Genomic Model Improves Risk Prediction for Coronary Artery Disease medrxiv.org/content/10.110… Awesome collaboration with Wallace Wang Pradeep Natarajan and enabled by UKBB and TOPMed Broad Institute

I'm thrilled to share our latest preprint on metabolic polygenic risk score🧬! We developed metabolic PRS using multi-ancestry GWAS of 22 metabolic traits from over 10 million people. w/ Alisa Chen, Yang Sui, Akl Fahed Patrick Ellinor Pradeep Natarajan, and more Thread🧵

NEW preprint led by Min Seo Kim, MD, MSDH Alisa Chen and Yang Sui Metabolic Polygenic Risk Scores for Prediction of Obesity, Type 2 Diabetes, and Related Morbidities O-MetPRS and D-MetPRS 🔹 Leverage 22 metabolic traits from over 10 million people 🔹Derived in UKB, validated

Delighted to share our AHA Science Scientific Statement on Direct-to-Consumer Genetic Testing for Cardiovascular Disease! ahajournals.org/doi/10.1161/CI… Circulation [1/3]

Delighted to share the preprint on the largest obesity GWAS to date! GWAS from >2 million participants Key: ✳️13% increase in loci discovery ✳️Identified 11 obesity genetic clusters (endotypes) ✳️Obesity management should be as diverse as the condition itself Thread👇