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João Sabino IBD Leuven with further fascinating insights of proteomics profiles in breast milk of IBD mothers . #DDW2022

A call to everyone involved in science. We have to do more reproducibility studies! We just can’t have a new biomarker every year that isn’t replicated/validated by others. Let’s prioritise this as a community. I promise this will make progress faster.

An absolute honour to visit the PREDICT IBD centre led by Tine Jess and so many brilliant scientists, statisticians, informaticians,… Impressive achievement. Such a warm and inspiring atmosphere. Looking forward to (predict ;-)) the future!

Douglas Altman (12 Jul 1948-3 June 2018) UK. “One of the most influential medical statisticians of the past 50 years”. Bradford Hill Medal 1997, BMJ Lifetime Achievement Award 2015, for spearheading reform of medical research reliability & reporting. 1/2

Interested to read more? Find out here ! tandfonline.com/doi/full/10.10…

Fantastic seminar talk ⁦Metabolism, Digestion & Reproduction⁩ by ⁦Bram Verstockt⁩ from ⁦IBD Leuven⁩ on #precisionMedicine in #IBD - demonstrating that it is more a hope than a hype, and combining networks with multiomics approaches may take us closer! Thanks Bram for coming

Comparative effectiveness studies for drug positioning, how fair are the comparisons Dahham Alsoud Bram Verstockt Severine Vermeire American Gastroenterological Association (AGA) CGH cghjournal.org/article/S1542-…

Holistic care in #IBD: time for patient-centric approaches ? Find out now Gut Journal ! #PSudhakar Judith Wellens João Sabino Severine Vermeire Bram Verstockt #MFerrante gut.bmj.com/content/early/…

Loved Ashwin,M.D talk today UMichGIHep-Fellowship #GIGRandRounds Kelly Cushing (+ Jeffrey Berinstein) Especially, loved Ashwin’s thoughtful approach to biomarkers. ▶️Number of studies on putative biomarkers in #IBD >>> actual clinical utility. 🔴What are we missing?

NEW PAPER Title says it all: there is no such thing as a validated prediction model doi.org/10.1186/s12916…

Towards a non-invasive blood test to #monitor endoscopy disease activity before and after therapy in patients with #CD? #EHI @DahhamAlsoud Prometheus Biosciences Bram Verstockt Severine Vermeire Y-ECCO #JCC academic.oup.com/ecco-jcc/advan…

#Seinfeld

Staggering how many excellent healthcare researchers refuse to engage with prediction models that present risk estimates. They rather push for classification or tests, even when they agree patient decisions are based on risk judgements & that risk thresholds vary ...

Beyond Discrimination: A Call for Comprehensive Assessment of Clinical Prediction Models in Inflammatory Bowel Disease Ben Van Calster academic.oup.com/ibdjournal/adv…

#Ustekinumab and #Vedolizumab Exposure Is #Unaffected by #Pharmacogenetic Determinants of #Anti-TNFs Pharmacokinetics. Dahham Alsoud et al now in IBDJournal & CC360. Read more academic.oup.com/ibdjournal/adv… Bram Verstockt Severine Vermeire João Sabino

We looked at dynamic random forest prediction models for central line-associated bloodstream infections on EHR from UZ Leuven. We compared binary, multiclass, time-to-event, and competing risk outcome definitions. With elena albu Laure Wynants @laurewynants.bsky.social arxiv.org/abs/2404.16127

NEW PREPRINT The harm of the use of imbalance correction methods on calibration, extending our earlier work on regression models to more complex techniques arxiv.org/abs/2404.19494

Is there a role for clinical decision support tools #CDST in IBD? Calibration, Clinical Utility and Specificity of #CDST in #IBD now in CGH ! Dahham Alsoud João Sabino #MFerrante Bram Verstockt Severine Vermeire cghjournal.org/article/S1542-…