We’re the PVD Council - obviously our dinner is going to be the best event of the night! Good food, great company, and unmatched trivia…who wouldn’t want a seat at our table for #AHA24 ? Tag someone that you’re interested in bringing with you to the dinner on Saturday! 🍽️

We’re thrilled to announce our partnership with the California Initiative to Advance Precision Medicine @CAL_HHS! Together, we’ll build on efforts throughout California to pave the way for more personalized approaches to prevent and treat disease. More ➡️ allof-us.org/3AGI6xB

Celebrating the work family with deep dish 🍕 #AHA24 AHA Science

3/ Key Findings: Disaggregated data show underrepresentation for Laotian, Cambodian, and Filipino Americans—worsening from medical school through faculty positions. For example: 📊 Filipino med school grads: RQ = 0.93

The GTEx V10 has been released. Compared to release V8, V10 has 12% more RNA-seq samples and 23% more samples used for eQTL analyses. V10 release includes new smallRNA-seq data from 16,760 tissue samples, including gene expression counts and cis-QTLs. It also includes deep

Applications are now open! Apply to the 2025 Broad Summer Scholars Program (BSSP) by January 22! BSSP is a 6-week summer program for highly motivated rising high school seniors with a strong interest in #science. Learn more at: broad.io/bssp #SummerPrograms

Tabula Sapiens 2.0, a reference atlas with >1.1 million cells from 28 human tissues, reveals insights into transcription factor expression, cell senescence, & sex-specific gene expression. Explore the findings: biorxiv.org/content/10.110…

Great Science Magazine perspective from Daniel J Drucker on weight loss-independent favorable effects of GLP-1R agonism. Important to note that Adrian “WE NEED RCTS!” Hernandez et al showed that albiglutide among individuals with T2D + CVD reduced MACE by 22% v placebo *without* weight change

86% of cardiovascular trials underrepresented Black, Hispanic/Latinx, and female patients in this new systematic review. #AHAJournals #ResearchLetter Scott Halpern PAIR Center Penn Medicine ahajrnls.org/3ZXpPVi

Trained on 9.3 trillion nucleotides from over 128,000 archaeal, prokaryotic, and eukaryotic genomes, Evo 2 brings the power of large language models to biology, enabling new discoveries in bioengineering and medicine. arcinstitute.org/news/blog/evo2

Alexandra Eala on what it means to be the 1st Filipino to beat a top 10 player “You have to ask the country 😂 Growing up it was tough.. you didn’t have anyone where you’re from to pave the way. I hope this takes Philippines tennis to another step” 🇵🇭🥹

Our study led by Alyssa M. Flores, MD & with Aniruddh Patel describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jamac… JAMA Cardiology

Nearly 1 in 3 with PAD without a history of smoking, DM2, or CKD have a high PAD polygenic risk score Alyssa M. Flores, MD Aniruddh Patel

Pleased to share our JAMA Cardiology study developing an improved polygenic score for PAD! Very grateful for mentorship from Aniruddh Patel and Pradeep Natarajan on this; and to work alongside Yunfeng Ruan🌻 #StandWithUkraine🌻 and the rest of our group! 🧬🧬 Broad Institute Mass General Heart Mass General Surgery

A new study using AllofUsResearch, @UK_Biobank & Mass General Brigham data shows a new polygenic risk score can predict peripheral artery disease w/ performance similar to knowing if someone has diabetes & even predicts outcomes like limb complications: allof-us.org/3FA9qjv

🔬👨🏻‍🔬 Dr. Nick Leeper receives his second NIH R35 Award 🤯 to explore the link between cancer and cardiovascular disease 🫀. Stanford CVI MD Anderson Cancer Center 🔗: vascular.stanford.edu/news/news25/le…

Big news: Massachusetts General Hospital ranks #1 in the world for high-impact research contributions among healthcare institutions, according to the 2024 Nature Index! 🌍 Mass General Transplant Mass General Surgery MGH Pathology Mass General Brigham Nephrology Mass General Brigham Research nature.com/nature-index/n…

⚡️Thrilled that #VirtualLab is published in nature! nature.com/articles/s4158… We created a team of AI agents to mirror my Stanford lab🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.

A new polygenic score estimated peripheral artery disease (PAD) and identified more cases of incident PAD when added to screening criteria. Alyssa M. Flores, MD Aniruddh Patel Pradeep Natarajan ja.ma/4mcexX7

Awesome and inspiring lab retreat, now joint with Zhi Yu Michael Honigberg, MD, MPP Akl Fahed labs! Our breadth is growing! Excited for next year with even more new PIs MGH Cardiovascular Research Center CGM at MGH Mass General Brigham Research Broad Institute Harvard Medical School