Thrilled to be in SF after years for #CROI2025

#CROI2025 Chris Beyrer makes an imp point: There is no HIV PrEP without PEPFAR. This will likely increase global HIV infections.. it’s a net loss situation.

#CROI2025 I get it goal is efficiency and savings. Look at what PEPFAR has achieved. PEPFAR is “efficient”. Please take a rational look Department of Government Efficiency Marco Rubio

CROI: Good summary of Dr. Beyrer's plenary at #CROI2025 - we have had so many successes in HIV treatment and prevention! The PEPFAR closures (USAID is an implementing partner) will set those back in big way. ajmc.com/view/global-st… via ajmc

#CROI2025 Onyema Ogbuagu presents 26-wk data on every 6month long acting regimen LEN+ monoclonal ab for HIV with 96% suppression! Alas, only ~40% eligible, and some failures with resistance. Not for everyone but prob useful in select cases. Look forward to longer term data .

NIH STOMP RCT provided definitive answers on the lack of clinical utility of tecovirimat monotherapy for treatment of clade II mpox The trial enrollment was stopped in late 2024 when an interim analysis showed that tecovirimat monotherapy was ineffective😔 nih.gov/news-events/ne…

Michael Rodgers JAMA ESCMID global. Staph aureus clinical trials session. April 12. 16:15

HIV RNA monitoring for people using oral tenofovir/XTC PrEP never quite made sense.. good to see data supporting lack of its utility. Hopefully CDC guideline will reflect this soon Paul Sax CDC #HIVTwitter #IDTwitter academic.oup.com/cid/advance-ar…

LENACAPAVIR: It happened early! Lenacapavir got approved by the FDA. This is super exciting! Super powerful HIV prevention drug nbcnews.com/health/health-…

So the Prasad hit job was two-prong. First there was a political hit, using many outdated clips, some taken out of context, some misleading and mostly irrelevant to his role, certainly not the focus of his career which was 500+ research publications, teaching and medical care.

Agree with John John Mandrola, MD Sad day indeed. My only hope is that this leads to some sort of awakening from both sides. open.substack.com/pub/johnmandro…

A dark shakespearean tragedy 👇 VP, the guy who spoke truth, is banished by both the sides trying to protect their vested interests. Sad for medicine.

To Those who had disagreed with Prasad’s appointment at FDA for any reason, this is your integrity test.. do u really want a world where a scientific officer and adjudicator is removed from service in this way??!!👇

Wow!! Some justice!

The anal cancer screening guidelines for PWH recommend testing every 1-2 yrs. But the evidence base is thin, the tests are meh, and resources are limited. Here's why guidelines may be racing ahead of the data (and certainly the resources). Amit Achhra, MD PhD MPH blogs.jwatch.org/hiv-id-observa…

Anal Cancer Screening in HIV: When Guidelines Get Ahead of the Evidence Read the latest in HIV and ID Observations from Paul Sax: jwat.ch/4fR8s03 #IDTwitter

Yes urge readers to see both sides as nicely captured in many of these comments (including mine ;) thnx Paul

PEPFAR Commits to Distributing Breakthrough HIV Drug Lenacapavir Demonstrating American Excellence in Science and American Leadership in HIV Prevention - United States Department of State state.gov/releases/the-u…

Anil Makam Have you read the recent article on this topic by Siddhartha Mukherjee in The New Yorker Anil ? newyorker.com/magazine/2025/…

Eye of the beholder No difference in overall mortality Massive overdiagnosis-many medicalized for no reason Screen 400+ men to avert 1 prostate ca death over 20+ years Doesn't include QoL harms of biopsies & treatment If honestly presented, many would say no thanks