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Delighted to have been awarded an HFSP (& EMBO) Long-Term Fellowships With Wickstrom-Lab at @MaxPlanckPress, we will decode and reconstitute the molecular logic of epigenetic mechanical memories in tissue regeneration (in vivo) 1/2 🗒️: hfsp.org/hfsp-news/fell…

In the latest issue! Mechanobiology: Shaping the future of cellular form and function dlvr.it/T7Vcvd

Our findings reveal how chemo-mechanical environment cues such as changes in cell extracellular matrix stiffness affect not only the availability of epigenetic regulators but also the mechanosensitive binding of heterochromatin to the nuclear lamina.

Loosely packaged DNA might make these nerve cells better able to encode memories go.nature.com/4dx4jw6

Congratulations to my officemate @KaitlinMccreery and to Aki Stubb on this 💎 paper The work shows how the #nucleus acts as a “signal integrator” for mechano-chemical cues to control cell fate transitions 💥 #Mechanobiology A 🧵: 👇

Can we map gut inflammation with ultrasound? Yes, using probiotic biosensors! 🔊 Imagine drinking a "diagnostic yogurt" and getting an ultrasound instead of endoscopy or colonoscopy 😁. Congrats to Marjorie Buss and collaborators on this advance. doi.org/10.1101/2024.0…

💫NEW by jared toettcher Harry McNamara & co: synthetic ‘signal-recording’ gene circuits on mouse #gastruloids show that cell sorting rearranges patchy domains of Wnt activity into a single pole that defines the anterior–posterior axis. 👉🏼rdcu.be/dVTQc nature.com/articles/s4155…

Glucose has a surprise role in directing cell fate and migration go.nature.com/4hcwMtM

Thrilled to share our new work bioRxiv: biorxiv.org/content/10.110… Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live cells. We reveal genome chromatin is essentially replicated from regions with greater nucleosome motions. 1/2

1. mitochondrial dynamics is broadly regulated by external forces including cell geometry, crowding, stretching, and shear stresses. All conditions that reduce actomyosin tension lead to shortened mitochondria.

1/4 In our new concept paper in Biological Theory, we elaborate an investigative approach that prioritizes the art of careful observation, the biological whole, and physical thinking in order to develop novel biological theories of morphogenesis. link.springer.com/article/10.100…

morning meditation

Congratulations to Sara Wickstrom-Lab for being named one of #50ScientistsThatInspire! So lucky to be inspired by her every day

How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse skin. 1/6 biorxiv.org/content/10.110…

saudade – the feeling of melancholy, longing and nostalgia

Trained immunity in the bone marrow: Hub of autoimmunity dlvr.it/TG4mqW

NEW RESEARCH—A case series provides evidence that CD19-targeting #CAR T-cell therapy might intercept with the progression of fibrotic organ manifestations in patients with #SystemicSclerosis thelancet.com/journals/lanrh…

Even after drastic weight loss, the body’s fat cells carry the ‘memory’ of obesity go.nature.com/3YRR9nr

“Wet dog shakes”—a common reflex behavior shared among many hairy mammals and designed to expel water and irritants from their coats—happens when particular mechanoreceptors are activated, researchers studying mice report in Science. Learn more: bit.ly/3ZnmPCU

A paradigm for biology is emerging in which cells can be genetically programmed to write their histories into their own genomes