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BSPR and EUPA #proteomics conference 2023 in Newcastle! Early bird registration deadline this weekend! British Society for Proteome Research News@EuPA

It’s been a great start to the week at the Matthias Trost 🇪🇺 lab retreat, a very productive couple of days! 🧪💭

Oh and this book we contributed a chapter to has arrived. Nice one Rachel Foreman Amy L. George Mariwan H Sayda, PhD Unfortunately only one copy..

A recent pre-print where we used mass spectrometry to demonstrate that the large rise in plasma GDF15 in pregnancy is fetally derived. Great to have played a small part in this important work on hyperemesis gravidarum. #teammasspec

Opening our final session is Ben Raymond Ben Raymond speaking about proteomic mapping of macrophage reprogramming in response to phagocytosis of apoptotic cells

Fresh data from the brand-new BrukerMassSpec timsTOF HT: human xenograft model in mouse liver. 500 ng protein digest, 1 hr gradient, diaPASEF with library, searched with DIA-NN: - 13,909 protein groups (of which >8,000 human) - 165 peptides - 953k PSMs

For readers interested in progress with kinase inhibitors in the past 20 years, and the future of kinase drug discovery, here's a review rdcu.be/dfphq

Do you have any questions about building your career? Then come by at our career session during #BSPREUPA2023! Our experts Anas Kamleh, Adam Hughes, Simon England, Anjali Seth, Chiara Francavilla, and Christian Moritz 👨‍🔬🎓🚴 ☮ will share their experiences and tips! #proteomics #careeradvice

Had an amazing time at the #BSPREUPA2023 social event at Wylam Brewery sponsored by BrukerMassSpec last night! Great food, drinks, and most importantly dancing 💃

And she's done it again! Congrats Leonie on winning 3rd place for the Best ECR Talks at #BSPREUPA2023. I'm very proud of you 💪🥳

Teamwork makes the dream work! Cheers to a successful #BSPREUPA2023🥂 Matthias Trost 🇪🇺 Amy L. George Frances Ruth Walker Ritika Chatterjee Ben Raymond Jack Atakan Arda Nalbant JL Marín-Rubio Andrew Frey NUPPA British Society for Proteome Research News@EuPA

Nausea and vomiting in pregnancy linked to hormone from fetus nature.com/articles/d4158… Thanks to Alice and Rachel for this very nice News and Views !

BREAKING NEWS! New study published in Nature suggests that in the future, #HG may be prevented by raising #GDF15 levels prior to pregnancy using a priming strategy. #hyperemesisgravidarum Read more: hyperemesis.org/news/nature2023

Our lab's paper on identifying the source and cause of morning sickness has just dropped. The culprit - GDF15, a protein hormone made in many organs. High levels in the plasma during pregnancy causes severe sickness in those women who have low normal levels.

Lovely to have supported this nature publication by using LC-MS to measure specific variants of GDF15 to elucidate its origin during pregnancy with Richard Kay - An extremely important study linking GDF15 to risk of hyperemesis gravidarum.

We quantified 1.498 million thermal stability measurements in cells and crude extracts treated with small molecule therapeutics and tool compounds! We interrogated on- and off-target effects to dissect direct ligand binding and indirect effects.biorxiv.org/content/10.110…

Latest from the Olsen lab led by Tanveer Batth: Streamlined proteome-wide identification of drug targets indicates organ-specific engagement with implications for drug development and discovery. #TeamMassSpec #proteomics biorxiv.org/content/10.110…

We have an MRC DTP PhD project up for grabs! We are looking to use mass spectrometry to study the penetration of peptide drugs into tissues, in particular incretin mimetics. Project will be partnered with Pharmaron

Not one to miss if you're attending ASMS this year!

Want to know why you get nausea in pregnancy? Come and chat - at poster ThP 167 #ASMS2024