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.Ben Sabari and fellow #UTSW researchers uncovered how gene fusions form biomolecular condensates that drive aggressive kidney cancers. Published in Cell, the findings suggest new treatment options and may hold promise for other types of cancer. bit.ly/4jDkmej

Targeting protein disorder: the next hurdle in drug discovery: nature.com/articles/s4157…

Need for speed: Mass photometry as a sample analysis tool for structural studies: Structure cell.com/structure/full…

Priyanka Dogra, PhD, a postdoctoral researcher at St. Jude, is investigating how nucleolar phase separation impacts ribosome formation and how disruptions in this process contribute to cancer. Her work is helping uncover new ways to fight cancer at the cellular level.

Architectural RNAs: blueprints for functional membraneless organelle assembly dlvr.it/TLKTCW

‘Intelligent’ proteins: link.springer.com/article/10.100…

Happy to share our recent paper in RSC Advances Royal Society of Chemistry from our collaborative effort with Dr. Maity Banibrata Maity Thapar Institute of Engineering & Technology Congratulations to our PhD student Mandeep Kaur Mandeep Kaur (She/ Her). Read our paper: pubs.rsc.org/en/content/art…

Awesome paper alert! Learn about spectrum of chromatin condensate morphologies due to elastocapillary effects (no, liquids do not need to be spherical!), from amazing Amy Strom & Hongbo Zhao, w/ important contributions from co-authors Eeftens, Haataja, Kosmrlj.

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975

Scientists have found a way to jam the inner workings of biomolecular condensates, revealing how these enigmatic cell structures actually work go.nature.com/3SZ1xHI

Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of Sofi Quinodoz & Lifei jiang w/ Denis LJ Lafontaine & Sebastian Klinge and other fantastic co-authors nature.com/articles/s4158…

Latest work on RNA condensation from the Banerjee lab, led by a superstar graduate student, Tharun Mahendran. Biomolecular condensates can enhance RNA percolation, leading to the emergence of multi-phasic RNA condensates. nature.com/articles/s4155…

Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function: Molecular Cell cell.com/molecular-cell…

Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior: nature.com/articles/s4146…

Congrats to Jing Jessica Zhao & Amy Strom on cool manuscript!!! Reveals how cell nucleus is a heterogeneous material, w chromatin organization controlling formation & phase behavior of nuclear condensates. #CellBiology #Chromatin #PhaseSeparation rdcu.be/evWxR

Before we’ve lost what we can’t rebuild: Hope for prion disease asbmb.org/asbmb-today/sc…

Happy to share our latest review article, highlighting how phase separation—driven by protein–protein and protein–RNA interactions—underpins the organization of ribosome assembly within the nucleolus. sciencedirect.com/science/articl…

Excited to share my first postdoc paper in Cell! We found that BRD4 transcriptional condensates act as a pH-sensitive “switch” to fine-tune inflammation. Huge thanks to my amazing mentors & collaborators!@XuZhouLab Ruslan Medzhitov Jonathan Kagan Ivan Zanoni

Excited to share our new Molecular Cell paper! We show that β-catenin is an adaptor that links canonical BAF (cBAF) with binding partners via IDR-domain interactions. (1/7) cell.com/molecular-cell…

Excited to share our new preprint on bioRxiv from our great team @EMBL! biorxiv.org/content/10.110… If the nucleolus is liquid-like, why does it often appear irregularly shaped in proliferating mammalian cells? What controls the nucleolar shape? #PhaseSeparation #Nucleolus