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Denali’s DNL310, a treatment for the rare lysosomal storage disorder Hunter syndrome, lowered the neurodegeneration marker NfL after two years of treatment. ow.ly/Z3WC50OVnk3

Working with @BaehreckeLab and a great team to organize the Autophagy and Disease Keystone Symposium this December! Join us to explore emerging autophagy and lysosome research in Keystone (joint with the Ubiquitin Biology and Disease meeting). keysym.us/KSAutophagy24

Merging #Ubiquitin biology, #Autophagy and diseases at Keystone Symposia 🙄 Exciting program, new discoveries & focus on trainees, pre-sking season. Real joy working with Cynthia Wolberger Anastasia Henry @BaehreckeLab 👍🫶 Application for abstracts and selected talks August 30 😊

This year's Grand Challenges in Parkinson's Disease meeting (Sept. 27-28) Van Andel Institute (VAI) has an exciting lineup of speakers ranging from physiology to pathology and cell biology! Register to join! Present posters! Network! vai.org/event/grand-ch…

Time to register for the Keystone Symposia #KSUbiquitin24 meeting, joint with #KSAutophagy24 ! Abstract and scholarship deadline Aug. 30.

🚨Deadline for abstract and scholarship consideration for the Autophagy and Disease Keystone Symposia is August 30th 🚨 Apply now and come join this exciting meeting (with Ubiquitin Biology and Disease) in Keystone this December! keysym.us/KSAutophagy24 #KSAutophagy24 #Lysosomes

New GCase probe alert from David Vocadlo's group! LysoFix-GBA allows the quantification of endolysosomal GCase activity in fixed cells. Nice addition to our lysosomal toolkit! It's been a great pleasure collaborating with David's team to test this out in cells!

It's not too late! There's still time to register for the Autophagy and Disease Keystone Symposium, joint with Ubiquitin Biology and Disease. Please join the organizers @BaehreckeLab Cynthia Wolberger Ivan Đikić for what looks to be a fantastic meeting! keysym.us/KSAutophagy24

Proud of another Halloween costume contest win for our group this year 🧙‍♀️

Beautiful new study identifying a role for stress granules in the stabilization and repair of damaged lysosomal membranes

Our paper showing that Rab12 activates LRRK2 by promoting its localization to damaged lysosomes is now out in eLife! elifesciences.org/articles/87255 A nice summary of the work can be found here: elifesciences.org/digests/87255/…

Are you thinking about how to advance #ParkinsonsDisease therapeutics in the preclinical space? Join us April 23/24 at this NINDS workshop organized by Bill Martin and me. Check out the line-up! I’m psyched for some lively discussion. event.roseliassociates.com/pdtherapeutics…

Excited for Denali to join AMP PDRD and work together with scientists from academia, industry, and the non-profit sectors to enable the identification of new biomarkers of PD and related diseases and accelerate the development of therapeutic approaches for PD!

We had a fantastic time collaborating with Ta-Chiang Liu and his team to assess the role of LRRK2 activity in Paneth cell dysfunction linked to Crohn's disease. Our paper is out today in Science Immunology! science.org/doi/10.1126/sc…

New research suggests that LRRK2 hyperactivity in intestinal macrophages causes Paneth cell defects in preclinical models and patients with Crohn’s disease. Learn more in Science Immunology: bit.ly/3Z1HbBs

Interested in doing an internship in industry exploring the mechanisms of lysosomal dysfunction associated with PD? Here's a great opportunity to work with an outstanding scientist in my team! dnli.wd1.myworkdayjobs.com/Internships/jo…

Excited to share that dosing has begun in the Denali Phase 2a "BEACON" study of the investigational therapeutic BIIB122 in Parkinson's disease patients that carry a variant in LRRK2! investors.denalitherapeutics.com/news-releases/…

🚨New job post alert 🚨 We are looking to recruit a talented in vivo scientist to support our growing Parkinson's disease portfolio. Please reach out if you are interested in learning more! denalitherapeutics.com/job?id=0844a51…