New research: Clinical determinants impacting overall survival of patients with operable brain metastases from non-small cell lung cancer: Non-small cell lung cancer (NSCLC) is currently the leading cause of cancer-related death worldwide, and… frontiersin.org/articles/10.33… #oncology

New content online: Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration dlvr.it/Sbptsg

Nanotech devised by Ludwig UChicago Medicine's Wenbin Lin, Kaiting Yang, Ralph Weichselbaum & team triggers immune responses against multiple cancers in mice. Combined with radio- or immunotherapy, it extends survival in models of pancreatic & brain cancer. bit.ly/3NcKRbO

Blocking a key immune protein improves radiation therapy for cancer | Biological Sciences Division | The University of Chicago biologicalsciences.uchicago.edu/news/features/…

Online Now: YTHDF2 inhibition potentiates radiotherapy antitumor efficacy dlvr.it/SpdYw0

🔥 Hot off the press: UChicagoCancerCenter researchers Liangliang Wang, PhD, Ralph Weichselbaum, Chuan He, PhD, and colleagues published an excellent paper in Journal of Clinical Investigation showing the rescue of #RadiationResistance with increased levels of #BAMBI in myeloid cells. University of Chicago Radiation Oncology

TGF-β pseudoreceptor BAMBI imrpoves antitumor effects by Radiation...potential clinical translation! jci.org/articles/view/… Thanks Dr. Weichselbaum Ralph Weichselbaum

A neural #epigenetic signature detectable via plasma analyses is prognostic in patients with #glioblastoma (#GBM) resembling an oligodendrocyte-precursor and neuronal-precursor cell-like state and showing increased neuro-to-glioma synapse formation. #NPC nature.com/articles/s4159…

.Liang Wang Connor Lynch Sean Pitroda, M.D. Andras Piffko KY Ralph Weichselbaum et al UChicago Medicine Ludwig Cancer review the immune response to #radiotherapy-induced anti-tumor effects, & the combination of immune checkpoint blockade w/ radiotherapy hubs.la/Q02xZVHL0

Kudos to Ralph Weichselbaum and colleagues on publishing an excellent article in Journal of Clinical Investigation demonstrating enhanced antitumor immunity with inhibition/deletion of m6A reader YTHDF1. UChicagoCancerCenter University of Chicago Radiation Oncology UChicago Chemistry Ludwig Cancer ow.ly/jWBh50TxaTa

📢 New in Cancer Cell: Radiotherapy is essential for local control—but can it unintentionally accelerate growth of distant metastases? We examine how RT-induced EGFR signaling and immune modulation may fuel metastatic progression. 🧠🧬🔬 Read: doi.org/10.1016/j.ccel…

🔥 Hot off the press: In a new nature study, Ernst Lengyel and team show that blocking NNMT in tumor-supporting cells restores immune response & stops ovarian cancer growth, offering a new strategy for hard to treat cancers. Lengyel Lab UChicago Obstetrics and Gynecology Department ow.ly/zzfZ50Wu3UW