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Aujourd’hui, nous annonçons le succès de l’étude clinique de mode d’action sur TOTUM•63, contre le prédiabète et les stades précoces du diabète de type 2. Dernière étape qui achève son développement clinique avec sa mise sur le marché en ligne de mire. ➡️bit.ly/3u4BOEm

Thank you AASLD for giving me this wonderful opportunity to discuss Bernie Efole’s work at #TLM2023! I even had the chance to get my revenge on my colleague Dr. Olivier Barbier! IUCPQ-ULaval

Congratulations Arianne and co-authors. Just in time for #PancakeTuesday

⭐️In Memoriam: Denis Richard 1953–2023⭐️ Thank you Endocrinology | Karger for allowing us to pay tribute to a great Québécois who had a profound impact on science and society IUCPQ-ULaval Université Laval karger.com/nen/article/do…

Honoured to have been awarded a Tier 2 Canada Research Chair #CRC in Metabolism and Sleep Neurobiology 🧠 Université Laval IUCPQ-ULaval

Exploratory physiological experiments are not clinical trials. Letter to the Editor at Cell Metabolism authors.elsevier.com/a/1i%7EWj5WXUl…

ICMJE defines clinical trials as "any research project that prospectively assigns people or a group of people to an intervention, with or without concurrent comparison or control groups, to study the relationship between a health-related intervention and a health outcome".

This implies that even basic mechanistic studies on exercise or diet, as well as physiological studies on healthy individuals undergoing exercise training, are now being labeled as "clinical trials" due to their potential health-related physiological outcomes.

We contend the ICMJE’s guidelines are unsuited for experimental physiological studies, as the outcomes of physiological experiments demonstrate the remarkable adaptability of the human body and are not consistent with clinical trials in patients, where the focus is on a disease.

Contemporary experimental physiological trials are often focused on revealing mechanisms to determine how a particular intervention, such as exercise or a diet, affects a particular physiological outcome and are thus hypothesis generating rather than hypothesis driven.

Forcing such trials to conform to a rigid registration process defining primary and secondary outcomes designed for de facto clinical trials is undermining human physiological research, and this requirement should be abolished.

We urge journals to adopt a more flexible stand, abandon the ICMJE guidelines and perhaps use a questionnaire for authors to fill out when submitting a paper that then determines if a study is a clinical trial or an experimental physiological study.

I am delighted to share that I have been promoted to Associate Professor as of today! Thanks to all my lab members, the students I have had the privilege of supervising and teaching since 2020, and all my wonderful colleagues and mentors. Looks like we will keep sciencing!! 🤩

Tenured. Thanks to all Kazak lab members - past and present - for their hard work, curiosity, and trust in the scientific process. Thanks to Morag Park's lab at McGill and Thomas Duchaine for their leadership. And thanks to the anonymous letter writers. Rosalind & Morris Goodman Cancer Institute McGill University

Maladie hépatique: un extrait du fruit camu-camu pour dégraisser le foie Andre Marette Faculté de médecine – Université Laval IUCPQ-ULaval ow.ly/ztH650T35Js

🤯Wow! Another outstanding study from Ana Domingos showing that peripheral vs central NPY has opposite effect on body weight independently of food intake!! nature.com/articles/s4158…

This is our first major paper of the lab showing early life modulation of T1D development, linked to maternal IgA deficiency. Super proud of the work twitterless Erinnand Luisa have done!

On #WorldDiabetesDay2024 congratulations to Professor Erin Mulvihill Heart Institute Ottawa University uOttawaBMI CIHR this years receipient of the early career investigator award from Diabetes Canada Felicitations! #diabetes

HUGE news! 🎉 Our lab just received a CIHR grant to study the impact of high fructose on the microbiome & gut-liver axis! A big thank you to Jonathan Schertzer (SchertzerLab) Andre Marette PatriciaMitchell PhD & reviewers. Exciting discoveries are on the horizon! Faculté de médecine – Université Laval IUCPQ-ULaval INAF

🎉 Exciting news! Led by Mackenzie Gutierrez, our latest on the gut mycobiome and its role in metabolic health is now published in Nature Communications ! 🧫🍄 Explore how fungal colonization influences obesity and metabolic inflammation in mice. shorturl.at/Sstq0 🧵