Brage Storstein Andresen (@andresenbrage) 's Twitter Profile
Brage Storstein Andresen

@andresenbrage

Professor of Human Molecular Genetics at SDU, Head of Section for Translational Biology. Interested in RNA biology, Splicing regulation and ASO therapy.

ID: 1301503286143574016

calendar_today03-09-2020 12:52:38

44 Tweet

243 Followers

465 Following

Brage Storstein Andresen (@andresenbrage) 's Twitter Profile Photo

Our new review is now in print: doi: 10.1002/humu.24306. onlinelibrary.wiley.com/share/author/Y… We review all known human disease-associated pseudoexons that carry functional splice sites and are activated by deep intronic sequence variants located outside splice site sequences.

Brage Storstein Andresen (@andresenbrage) 's Twitter Profile Photo

Pseudoexon activation in disease by non‐splice site deep intronic sequence variation — wild type pseudoexons constitute high‐risk sites in the human genome onlinelibrary.wiley.com/doi/10.1002/hu…

Wiley Biomedical Science (@wileybiomedical) 's Twitter Profile Photo

Vulnerable #exons, like ACADM exon 5, are highly dependent on maintaining a correct balance between splicing enhancers and silencers. Read Human Mutation’s latest Editor’s Choice article, by Lise L. Holm & team from Uni Southern Denmark: ow.ly/c57Q50HGRb2 Brage Storstein Andresen

Vulnerable #exons, like ACADM exon 5, are highly dependent on maintaining a correct balance between splicing enhancers and silencers.

Read Human Mutation’s latest Editor’s Choice article, by Lise L. Holm &amp; team from <a href="/UniSouthDenmark/">Uni Southern Denmark</a>: ow.ly/c57Q50HGRb2

<a href="/AndresenBrage/">Brage Storstein Andresen</a>
Brage Storstein Andresen (@andresenbrage) 's Twitter Profile Photo

Vulnerable exons, like ACADM exon 5, are highly dependent on maintaining a correct balance between splicing enhancers and silencers onlinelibrary.wiley.com/doi/10.1002/hu…

Jake June-Koo Lee (@jakelee0711) 's Twitter Profile Photo

What a striking finding on questionable driver -- KRAS Q61K mutation. It seems like this is functional only when this coexists with adjacent silent mutation in G60 that abolishes cryptic splice site. Shocking deep biology from TKI resistance research. nature.com/articles/s4158…

Brage Storstein Andresen (@andresenbrage) 's Twitter Profile Photo

Check out our latest paper from our collaboration with Barbara Guerra's lab doi.org/10.1007/s00018… We show that protein kinase CK2α is essential for maintaining the stability of the replisome machinery and for optimizing ATR-CHK1 signalling activation upon replication stress.

Check out our latest paper from our collaboration with Barbara Guerra's lab

doi.org/10.1007/s00018…

We show that protein kinase CK2α is essential for maintaining the stability of the replisome machinery and for optimizing ATR-CHK1 signalling activation upon replication stress.
Brage Storstein Andresen (@andresenbrage) 's Twitter Profile Photo

Great to see this published! Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation academic.oup.com/nar/advance-ar…

Brage Storstein Andresen (@andresenbrage) 's Twitter Profile Photo

Check out the latest paper from our collaboration with Birgitta Knudsen's lab. Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation academic.oup.com/nar/article/50…

Brage Storstein Andresen (@andresenbrage) 's Twitter Profile Photo

We're excited to present VulExMap, a new software to predict if exons are vulnerable to exonic splicing mutations. All exons are not created equal - Exon vulnerability determines the effect of exonic mutations on splicing biorxiv.org/content/10.110…

Marquardt Laboratory (@marquardtlab) 's Twitter Profile Photo

Great lineup for the 8th Danish RNA society meeting 10th October 2023 in wonderful Odense! Sign up here: danish-rna-society.nemtilmeld.dk/4/

Great lineup for the 8th Danish RNA society meeting 10th October 2023 in wonderful Odense! 
Sign up here: danish-rna-society.nemtilmeld.dk/4/
Brage Storstein Andresen (@andresenbrage) 's Twitter Profile Photo

It is time to sign up for the Danish RNA Society’s 8th Annual Meeting on RNA Deadline for registration: 30 September 2023 at 11:55 pm danish-rna-society.nemtilmeld.dk/4/ Deadline for submission of abstract: 20 September 2023 at 11:55 pm Send abstract to [email protected]

It is time to sign up for the Danish RNA Society’s 8th Annual Meeting on RNA

Deadline for registration: 30 September 2023 at 11:55 pm
danish-rna-society.nemtilmeld.dk/4/
Deadline for submission of abstract: 20 September 2023 at 11:55 pm
Send abstract to trinemh@inano.au.dk
Brage Storstein Andresen (@andresenbrage) 's Twitter Profile Photo

Our paper where we demonstrate the power of up-regulating gene expression by blocking wild type pseudoexon inclusion is finally out in Molecular Therapy – Nucleic Acids. doi.org/10.1016/j.omtn…

Jan-Wilhelm Kornfeld 🇺🇦🇮🇱🇵🇸 (@kornfeld_janw) 's Twitter Profile Photo

We have a postdoc opening 👩‍🔬🧑‍🔬in our lab aiming to investigate paracrine miRNAs🧬 crosstalk in obese adipose tissue. Find more information on the project here: linkedin.com/feed/update/ur… Please help us spreading the word by RT'ing ↩️

We have a postdoc opening 👩‍🔬🧑‍🔬in our lab aiming to investigate paracrine miRNAs🧬 crosstalk in obese adipose tissue. Find more information on the project here:
linkedin.com/feed/update/ur…

Please help us spreading the word by RT'ing ↩️
Brage Storstein Andresen (@andresenbrage) 's Twitter Profile Photo

After years of hard work our new paper on Vulnerable exons is now published in Nucleic Acids Research. We're excited to present VulExMap, a new software to predict if exons are vulnerable to exonic splicing mutations. academic.oup.com/nar/advance-ar…

After years of hard work our new paper on Vulnerable exons is now published in Nucleic Acids Research. 
We're excited to present VulExMap, a new software to predict if exons are vulnerable to exonic splicing mutations. academic.oup.com/nar/advance-ar…
Lourdes Ruiz Desviat (@lrdesviat) 's Twitter Profile Photo

New paper from the lab in Nucleic Acid Therapeutics Oligonucleotide Therapeutics Society journal, in collaboration with Brage Storstein Andresen 👇👇👇 Antisense oligonucleotides as potential therapy for PKU splice variants COST DARTER @CBMSeveroOchoa CIBERER CEDEM #PKU #AON #CRISPR

Brage Storstein Andresen (@andresenbrage) 's Twitter Profile Photo

Now published on paper. All exons are not created equal—exon vulnerability determines the effect of exonic mutations on splicing academic.oup.com/nar/article/52…