🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Our new review is now in print: doi: 10.1002/humu.24306. onlinelibrary.wiley.com/share/author/Y… We review all known human disease-associated pseudoexons that carry functional splice sites and are activated by deep intronic sequence variants located outside splice site sequences.

Pseudoexon activation in disease by non‐splice site deep intronic sequence variation — wild type pseudoexons constitute high‐risk sites in the human genome onlinelibrary.wiley.com/doi/10.1002/hu…

Vulnerable #exons, like ACADM exon 5, are highly dependent on maintaining a correct balance between splicing enhancers and silencers. Read Human Mutation’s latest Editor’s Choice article, by Lise L. Holm & team from Uni Southern Denmark: ow.ly/c57Q50HGRb2 Brage Storstein Andresen

Vulnerable exons, like ACADM exon 5, are highly dependent on maintaining a correct balance between splicing enhancers and silencers onlinelibrary.wiley.com/doi/10.1002/hu…

What a striking finding on questionable driver -- KRAS Q61K mutation. It seems like this is functional only when this coexists with adjacent silent mutation in G60 that abolishes cryptic splice site. Shocking deep biology from TKI resistance research. nature.com/articles/s4158…

Check out our latest paper from our collaboration with Barbara Guerra's lab doi.org/10.1007/s00018… We show that protein kinase CK2α is essential for maintaining the stability of the replisome machinery and for optimizing ATR-CHK1 signalling activation upon replication stress.

Great to see this published! Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation academic.oup.com/nar/advance-ar…

Check out the latest paper from our collaboration with Birgitta Knudsen's lab. Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation academic.oup.com/nar/article/50…

Great work!!! Such an honour to participate!!

We're excited to present VulExMap, a new software to predict if exons are vulnerable to exonic splicing mutations. All exons are not created equal - Exon vulnerability determines the effect of exonic mutations on splicing biorxiv.org/content/10.110…

Great lineup for the 8th Danish RNA society meeting 10th October 2023 in wonderful Odense! Sign up here: danish-rna-society.nemtilmeld.dk/4/

It is time to sign up for the Danish RNA Society’s 8th Annual Meeting on RNA Deadline for registration: 30 September 2023 at 11:55 pm danish-rna-society.nemtilmeld.dk/4/ Deadline for submission of abstract: 20 September 2023 at 11:55 pm Send abstract to [email protected]

Great talk from Ainhoa Martinez-Pizarro at #OTS2023 meeting on our collaborative work with Jose Lucas Lab and Brage Storstein Andresen on ASO for idiopathic autism and schizophrenia @CBMSO_CSIC_UAM Oligonucleotide Therapeutics Society

Our paper where we demonstrate the power of up-regulating gene expression by blocking wild type pseudoexon inclusion is finally out in Molecular Therapy – Nucleic Acids. doi.org/10.1016/j.omtn…

We have a postdoc opening 👩‍🔬🧑‍🔬in our lab aiming to investigate paracrine miRNAs🧬 crosstalk in obese adipose tissue. Find more information on the project here: linkedin.com/feed/update/ur… Please help us spreading the word by RT'ing ↩️

After years of hard work our new paper on Vulnerable exons is now published in Nucleic Acids Research. We're excited to present VulExMap, a new software to predict if exons are vulnerable to exonic splicing mutations. academic.oup.com/nar/advance-ar…

New paper from the lab in Nucleic Acid Therapeutics Oligonucleotide Therapeutics Society journal, in collaboration with Brage Storstein Andresen 👇👇👇 Antisense oligonucleotides as potential therapy for PKU splice variants COST DARTER @CBMSeveroOchoa CIBERER CEDEM #PKU #AON #CRISPR

Now published on paper. All exons are not created equal—exon vulnerability determines the effect of exonic mutations on splicing academic.oup.com/nar/article/52…

Interested in neuronal #microexons? #splicing? #antisense? #autism? Check out our new preprint👇👇 Centro de Biología Molecular Severo Ochoa Jose Lucas Lab Brage Storstein Andresen UAM Autónoma Madrid biorxiv.org/content/10.110…